RNA Landscapes of Brain and Brain-Derived Extracellular Vesicles in Simian Immunodeficiency Virus Infection and Central Nervous System Pathology

• Published in: The Journal of infectious diseases Vol. 229; no. 5; pp. 1295 - 1305
• Main Authors: Huang, Yiyao, Abdelgawad, Ahmed, Turchinovich, Andrey, Queen, Suzanne, Abreu, Celina Monteiro, Zhu, Xianming, Batish, Mona, Zheng, Lei, Witwer, Kenneth W
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 15.05.2024
• Subjects: Animals; Brain - metabolism; Brain - pathology; Brain - virology; Central nervous system; Central Nervous System - metabolism; Central Nervous System - pathology; Central Nervous System - virology; Chronic infection; Circular RNA; Encephalitis; Extracellular vesicles; Extracellular Vesicles - metabolism; HIV; Human immunodeficiency virus; Immune response; Immune system; Infections; Inflammation; Macaca mulatta; Major; Male; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Molecular modelling; Nervous system; Occipital lobe; Pathology; Ribonucleic acid; RNA; RNA viruses; RNA, Circular - genetics; RNA, Circular - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Simian Acquired Immunodeficiency Syndrome - pathology; Simian Acquired Immunodeficiency Syndrome - virology; Simian Immunodeficiency Virus - genetics; SIV; circRNAs; extracellular vesicles; bdEVs; HIV; miRNAs; exosomes; mRNAs; HAND; ectosomes

Abstract Background Brain tissue-derived extracellular vesicles (bdEVs) act locally in the central nervous system (CNS) and may indicate molecular mechanisms in human immunodeficiency virus (HIV) CNS pathology. Using brain homogenate (BH) and bdEVs from a simian immunodeficiency virus (SIV) model of...