Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release

• Published in: Bioengineering (Basel) Vol. 11; no. 7; p. 649
• Main Authors: Sharma, Manoj B., Abdelmohsen, Hend A. M., Kap, Özlem, Kilic, Volkan, Horzum, Nesrin, Cheneler, David, Hardy, John G.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.06.2024
• Subjects: 17β-Estradiol; Antibiotics; Arrays; Biological activity; Composite materials; Curing; Design; Drug delivery; Drug delivery systems; estradiol; Hydrogels; Mechanical properties; Medical research; Melatonin; Meropenem; microneedles; Needles; Polyhydroxyethyl methacrylate; Sex hormones; Silicones; Skin; Soft tissues; Surfactants; United Kingdom > UK; United States > US; meropenem; microneedles; hydrogels; drug delivery; melatonin; estradiol

Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here, we demonstrate the release of bioactive molecules (estradiol, melatonin and meropenem) from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel...