Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release

Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here, we demonstrate the release of bioactive molecules (estradiol, melatonin and meropenem) from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel...

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Published inBioengineering (Basel) Vol. 11; no. 7; p. 649
Main Authors Sharma, Manoj B., Abdelmohsen, Hend A. M., Kap, Özlem, Kilic, Volkan, Horzum, Nesrin, Cheneler, David, Hardy, John G.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 25.06.2024
Subjects
17β-Estradiol
Antibiotics
Arrays
Biological activity
Composite materials
Curing
Design
Drug delivery
Drug delivery systems
estradiol
Hydrogels
Mechanical properties
Medical research
Melatonin
Meropenem
microneedles
Needles
Polyhydroxyethyl methacrylate
Sex hormones
Silicones
Skin
Soft tissues
Surfactants
United Kingdom > UK
United States > US
meropenem
microneedles
hydrogels
drug delivery
melatonin
estradiol
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Abstract Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here, we demonstrate the release of bioactive molecules (estradiol, melatonin and meropenem) from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches in vitro. The pHEMA hydrogel microneedles had mechanical properties that were sufficiently robust to penetrate soft tissues (exemplified here by phantom tissues). The bioactive release from the pHEMA hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application in the transdermal delivery of bioactives (exemplified here by estradiol, melatonin and meropenem) for the treatment of various conditions.
AbstractList Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here, we demonstrate the release of bioactive molecules (estradiol, melatonin and meropenem) from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches in vitro. The pHEMA hydrogel microneedles had mechanical properties that were sufficiently robust to penetrate soft tissues (exemplified here by phantom tissues). The bioactive release from the pHEMA hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application in the transdermal delivery of bioactives (exemplified here by estradiol, melatonin and meropenem) for the treatment of various conditions.
Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here, we demonstrate the release of bioactive molecules (estradiol, melatonin and meropenem) from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches in vitro. The pHEMA hydrogel microneedles had mechanical properties that were sufficiently robust to penetrate soft tissues (exemplified here by phantom tissues). The bioactive release from the pHEMA hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application in the transdermal delivery of bioactives (exemplified here by estradiol, melatonin and meropenem) for the treatment of various conditions.Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here, we demonstrate the release of bioactive molecules (estradiol, melatonin and meropenem) from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches in vitro. The pHEMA hydrogel microneedles had mechanical properties that were sufficiently robust to penetrate soft tissues (exemplified here by phantom tissues). The bioactive release from the pHEMA hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application in the transdermal delivery of bioactives (exemplified here by estradiol, melatonin and meropenem) for the treatment of various conditions.
Author Kap, Özlem
Horzum, Nesrin
Hardy, John G.
Sharma, Manoj B.
Cheneler, David
Kilic, Volkan
Abdelmohsen, Hend A. M.
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CitedBy_id crossref_primary_10_1016_j_asems_2025_100139
crossref_primary_10_1016_j_ijbiomac_2025_140477
crossref_primary_10_3390_gels11030206
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Snippet Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here,...
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SubjectTerms 17β-Estradiol
Antibiotics
Arrays
Biological activity
Composite materials
Curing
Design
Drug delivery
Drug delivery systems
estradiol
Hydrogels
Mechanical properties
Medical research
Melatonin
Meropenem
microneedles
Needles
Polyhydroxyethyl methacrylate
Sex hormones
Silicones
Skin
Soft tissues
Surfactants
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Title Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release
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