Widespread context dependency of microRNA-mediated regulation

• Published in: Genome research Vol. 24; no. 6; pp. 906 - 919
• Main Authors: Erhard, Florian, Haas, Jürgen, Lieber, Diana, Malterer, Georg, Jaskiewicz, Lukasz, Zavolan, Mihaela, Dölken, Lars, Zimmer, Ralf
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.06.2014
• Subjects: Cell Line, Tumor; Conserved Sequence; Gene Regulatory Networks; Gene Silencing; Genome, Human; Humans; MicroRNAs - genetics; MicroRNAs - metabolism; Nucleotide Motifs; RNA, Messenger - genetics; RNA, Messenger - metabolism

Gene expression is regulated in a context-dependent, cell-type-specific manner. Condition-specific transcription is dependent on the presence of transcription factors (TFs) that can activate or inhibit its target genes (global context). Additional factors, such as chromatin structure, histone, or DN...