Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition

• Published in: mBio Vol. 11; no. 3
• Main Authors: Tal, Michal Caspi, Torrez Dulgeroff, Laughing Bear, Myers, Lara, Cham, Lamin B, Mayer-Barber, Katrin D, Bohrer, Andrea C, Castro, Ehydel, Yiu, Ying Ying, Lopez Angel, Cesar, Pham, Ed, Carmody, Aaron B, Messer, Ronald J, Gars, Eric, Kortmann, Jens, Markovic, Maxim, Hasenkrug, Michaela, Peterson, Karin E, Winkler, Clayton W, Woods, Tyson A, Hansen, Paige, Galloway, Sarah, Wagh, Dhananjay, Fram, Benjamin J, Nguyen, Thai, Corey, Daniel, Kalluru, Raja Sab, Banaei, Niaz, Rajadas, Jayakumar, Monack, Denise M, Ahmed, Aijaz, Sahoo, Debashis, Davis, Mark M, Glenn, Jeffrey S, Adomati, Tom, Lang, Karl S, Weissman, Irving L, Hasenkrug, Kim J
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 23.06.2020
• Subjects: A549 Cells; Adaptive Immunity - immunology; Animals; Betacoronavirus - immunology; CD47; CD47 Antigen - genetics; CD47 Antigen - metabolism; Cell Line, Tumor; Cytokines - immunology; Female; host response; Host-Microbe Biology; Humans; immune checkpoint; Immunity, Innate - immunology; Immunomodulation - immunology; innate immunity; Lymphocytic choriomeningitis virus - immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mycobacterium tuberculosis - immunology; pathogen recognition receptors; Receptors, Pattern Recognition - immunology; SARS-CoV-2; Up-Regulation - immunology; host response; CD47; pathogen recognition receptors; innate immunity; immune checkpoint

It is well understood that the adaptive immune response to infectious agents includes a modulating suppressive component as well as an activating component. We now show that the very early innate response also has an immunosuppressive component. Infected cells upregulate the CD47 "don't ea...