Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history

• Published in: Microbial genomics Vol. 7; no. 2
• Main Authors: Coscolla, Mireia, Gagneux, Sebastien, Menardo, Fabrizio, Loiseau, Chloé, Ruiz-Rodriguez, Paula, Borrell, Sonia, Otchere, Isaac Darko, Asante-Poku, Adwoa, Asare, Prince, Sánchez-Busó, Leonor, Gehre, Florian, Sanoussi, C. N’Dira, Antonio, Martin, Affolabi, Dissou, Fyfe, Janet, Beckert, Patrick, Niemann, Stefan, Alabi, Abraham S., Grobusch, Martin P., Kobbe, Robin, Parkhill, Julian, Beisel, Christian, Fenner, Lukas, Böttger, Erik C., Meehan, Conor J., Harris, Simon R., de Jong, Bouke C., Yeboah-Manu, Dorothy, Brites, Daniela
• Format: Journal Article
• Language: English
• Published: England Microbiology Society 01.02.2021
• Subjects: Africa, Eastern; Africa, Western; Drug Resistance, Bacterial; Evolution, Molecular; Genome, Bacterial; High-Throughput Nucleotide Sequencing; Humans; Mycobacterium tuberculosis - classification; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - isolation & purification; Phylogeny; Phylogeography; Tuberculosis - microbiology; Whole Genome Sequencing - methods; Africa, Eastern; Africa, Western; genome; diversity; evolution; Mycobacterium tuberculosis; mycobacteria; Mycobacterium africanum

Human tuberculosis (TB) is caused by members of the Mycobacterium tuberculosis complex (MTBC). The MTBC comprises several human-adapted lineages known as M. tuberculosis sensu stricto , as well as two lineages (L5 and L6) traditionally referred to as Mycobacterium africanum . Strains of L5 and L6 ar...