HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses

• Published in: mBio Vol. 5; no. 4; pp. e01318 - e01314
• Main Authors: Yan, Zhipeng, Bryant, Kevin F, Gregory, Sean M, Angelova, Magdalena, Dreyfus, David H, Zhao, Xue Zhi, Coen, Donald M, Burke, Jr, Terrence R, Knipe, David M
• Format: Journal Article
• Language: English
• Published: United States American Society of Microbiology 01.07.2014; American Society for Microbiology
• Subjects: Antiviral Agents - pharmacology; Cell Line; Cytomegalovirus - drug effects; Herpesvirus 1, Human - drug effects; Herpesvirus 2, Human - drug effects; Herpesvirus 8, Human - drug effects; HIV Integrase Inhibitors - pharmacology; Humans; Simplexvirus - drug effects; Virus Replication - drug effects

The catalytic site of the HIV integrase is contained within an RNase H-like fold, and numerous drugs have been developed that bind to this site and inhibit its activity. Herpes simplex virus (HSV) encodes two proteins with potential RNase H-like folds, the infected cell protein 8 (ICP8) DNA-binding...