Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization

• Published in: Molecular human reproduction Vol. 23; no. 9; pp. 646 - 653
• Main Authors: Camden, Alison J., Szwarc, Maria M., Chadchan, Sangappa B., DeMayo, Francesco J., O'Malley, Bert W., Lydon, John P., Kommagani, Ramakrishna
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.09.2017
• Subjects: Animals; Cell Differentiation; Decidua - cytology; Decidua - drug effects; Decidua - metabolism; Epithelial Cells - cytology; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Female; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; Forkhead Box Protein O1 - genetics; Forkhead Box Protein O1 - metabolism; Gene Expression Regulation, Developmental; Humans; Insulin-Like Growth Factor Binding Protein 1 - genetics; Insulin-Like Growth Factor Binding Protein 1 - metabolism; Mice; Mice, Knockout; Mifepristone - pharmacology; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Nuclear Receptor Coactivator 2 - antagonists & inhibitors; Nuclear Receptor Coactivator 2 - genetics; Nuclear Receptor Coactivator 2 - metabolism; Original Research; Pregnancy; Primary Cell Culture; Progesterone - pharmacology; Prolactin - genetics; Prolactin - metabolism; Receptors, Progesterone - antagonists & inhibitors; Receptors, Progesterone - deficiency; Receptors, Progesterone - genetics; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Signal Transduction; Stromal Cells - cytology; Stromal Cells - drug effects; Stromal Cells - metabolism; Wnt4 Protein - genetics; Wnt4 Protein - metabolism; endometrium; gene transcription; differentiation; decidualization; progesterone

Is Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization? GREB1 is a novel progesterone-responsive gene required for progesterone-driven human endometrial stromal cell (HESC) decidualization. Successful establishment of pre...