Modulation of activity and conduction in single dorsal column axons by kilohertz-frequency spinal cord stimulation

• Published in: Journal of neurophysiology Vol. 117; no. 1; pp. 136 - 147
• Main Authors: Crosby, Nathan D., Janik, John J., Grill, Warren M.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.01.2017
• Series: Nervous System Pathophysiology
• Subjects: Action Potentials - physiology; Animals; Axons - physiology; Biophysical Phenomena; Biophysics; Disease Models, Animal; Electric Stimulation; Hyperalgesia - etiology; Hyperalgesia - therapy; Male; Neuralgia - complications; Neuralgia - therapy; Neurons - physiology; Pain Measurement; Pain Threshold - physiology; Rats; Rats, Sprague-Dawley; Spinal Cord - cytology; Spinal Cord - physiology; Spinal Cord Stimulation - methods; kilohertz frequency; dorsal column; pain; spinal cord stimulation; axon

Kilohertz-frequency spinal cord stimulation (KHF-SCS) is a potential paresthesia-free treatment for chronic pain. However, the effects of KHF-SCS on spinal dorsal column (DC) axons and its mechanisms of action remain unknown. The objectives of this study were to quantify activation and conduction bl...