Role of Leucine in the Regulation of Protein Metabolism
Studies both in vivo and in vitro have shown that leucine at a very high dose can stimulate muscle protein synthesis, an effect that is enhanced in vivo by insulin secreted in response to the leucine dose. High leucine can also inhibit protein degradation in skeletal muscle, as well as in liver. In...
Saved in:
| Published in | The Journal of nutrition Vol. 135; no. 6S; pp. 1553 - 1556 |
|---|---|
| Main Author | |
| Format | Journal Article Conference Proceeding |
| Language | English |
| Published |
Bethesda, MD
American Society for Nutritional Sciences
01.06.2005
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Studies both in vivo and in vitro have shown that leucine at a very high dose can stimulate muscle protein synthesis, an effect that is enhanced in vivo by insulin secreted in response to the leucine dose. High leucine can also inhibit protein degradation in skeletal muscle, as well as in liver. In contrast, at normal physiological levels, increasing leucine concentration by infusion stimulates muscle protein synthesis by enhancing its sensitivity to insulin. It is concluded that the role of leucine in vivo is to provide a signal that amino acids are available, which in combination with the signal of energy availability from insulin, stimulates muscle protein synthesis. |
|---|---|
| AbstractList | Studies both in vivo and in vitro have shown that leucine at a very high dose can stimulate muscle protein synthesis, an effect that is enhanced in vivo by insulin secreted in response to the leucine dose. High leucine can also inhibit protein degradation in skeletal muscle, as well as in liver. In contrast, at normal physiological levels, increasing leucine concentration by infusion stimulates muscle protein synthesis by enhancing its sensitivity to insulin. It is concluded that the role of leucine in vivo is to provide a signal that amino acids are available, which in combination with the signal of energy availability from insulin, stimulates muscle protein synthesis. |
| Author | Garlick, Peter J |
| Author_xml | – sequence: 1 fullname: Garlick, Peter J |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16892269$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15930468$$D View this record in MEDLINE/PubMed |
| BookMark | eNpFkDtvwjAUha2KqjzatWObpWPgXjvxY6xQXxJVKyiz5Tg2DQoOisPQf98gkJjucL5zpPuNySA0wRFyjzBFUGy2DTNk-ZRPMc9ZvCIjzDNMOQIMyAiA0pQh50MyjnELAJgpeUOGmCsGGZcjIpZN7ZLGJwt3sFVwSRWS7tclS7c51KarmnAMv9umc33y6TpTNHUVd7fk2ps6urvznZD168vP_D1dfL19zJ8Xqc1y1qUWpLBCqtIVlipHGS0VOmEEFWXBvWcgi5IrJcoyAyakRwo0s0VGSy8kIpuQ6WnXtk2MrfN631Y70_5pBH00oLdB9wY010cDq77wcCrsD8XOlRf8_HIPPJ0BE62pfWuCreKF41JRylXPPZ44bxptNm3PrFcUkEEvFzFH9g_Qk21j |
| CODEN | JONUAI |
| CitedBy_id | crossref_primary_10_1007_s11802_015_2387_5 crossref_primary_10_1016_j_idairyj_2018_08_002 crossref_primary_10_1016_j_anifeedsci_2020_114710 crossref_primary_10_2527_jas_2010_3400 crossref_primary_10_1016_j_febslet_2007_06_043 crossref_primary_10_1016_j_foodchem_2020_126514 crossref_primary_10_3892_or_2016_4877 crossref_primary_10_1016_j_ramd_2015_04_004 crossref_primary_10_1152_ajprenal_00012_2018 crossref_primary_10_1016_j_bpg_2006_02_001 crossref_primary_10_1007_s00726_010_0799_5 crossref_primary_10_1093_ajcn_nqaa323 crossref_primary_10_1093_jn_136_1_234S crossref_primary_10_1002_oby_24022 crossref_primary_10_1007_s10552_013_0316_8 crossref_primary_10_1016_j_cbpa_2018_11_019 crossref_primary_10_3390_dairy4040041 crossref_primary_10_1016_j_ymben_2013_12_001 crossref_primary_10_1186_1475_2891_12_86 crossref_primary_10_1016_j_jbiosc_2016_07_008 crossref_primary_10_1016_j_jtherbio_2020_102780 crossref_primary_10_1249_01_mss_0000222836_66391_35 crossref_primary_10_1007_s13105_018_0646_9 crossref_primary_10_1139_apnm_2018_0765 crossref_primary_10_2527_jas_2016_0697 crossref_primary_10_1186_s12877_019_1200_5 crossref_primary_10_3177_jnsv_54_460 crossref_primary_10_1039_D3SC05629E crossref_primary_10_2217_17460875_3_1_43 crossref_primary_10_1007_s00726_012_1436_2 crossref_primary_10_1186_s12885_016_2811_2 crossref_primary_10_1177_0148607112460682 crossref_primary_10_3923_jbs_2018_506_513 crossref_primary_10_3945_jn_114_204305 crossref_primary_10_1097_MCO_0b013e3283139489 crossref_primary_10_1210_jc_2009_2128 crossref_primary_10_1590_S1984_82502010000100004 crossref_primary_10_4163_kjn_2009_42_8_714 crossref_primary_10_1016_j_aquaculture_2012_05_013 crossref_primary_10_1016_j_nutres_2017_08_004 crossref_primary_10_3390_metabo12060545 crossref_primary_10_1042_BST0340213 crossref_primary_10_1152_ajpregu_00115_2019 crossref_primary_10_1038_s41598_017_11834_5 crossref_primary_10_1186_s12986_016_0072_3 crossref_primary_10_3945_jn_110_127647 crossref_primary_10_1016_j_jnutbio_2012_01_001 crossref_primary_10_3390_ijerph17113871 crossref_primary_10_3945_an_115_011221 crossref_primary_10_1021_acs_jafc_8b00330 crossref_primary_10_1371_journal_pone_0001875 crossref_primary_10_1093_jn_nxab055 crossref_primary_10_1016_j_ijbiomac_2022_07_036 crossref_primary_10_1016_j_smallrumres_2022_106812 crossref_primary_10_1123_ijspp_2018_0579 crossref_primary_10_4162_nrp_2010_4_2_106 crossref_primary_10_3390_antiox7100148 crossref_primary_10_1007_s11745_007_3029_5 crossref_primary_10_3390_nu7053914 crossref_primary_10_4162_nrp_2017_11_2_121 crossref_primary_10_1071_EN10084 crossref_primary_10_1016_j_anifeedsci_2010_02_008 crossref_primary_10_1016_j_jnutbio_2006_07_005 crossref_primary_10_1017_S0007114516003767 crossref_primary_10_3177_jnsv_55_44 crossref_primary_10_1016_j_nut_2013_01_022 crossref_primary_10_3389_fphar_2022_859628 crossref_primary_10_1016_j_nutres_2017_12_003 crossref_primary_10_1111_jpc_12893 crossref_primary_10_2165_00007256_200737100_00005 crossref_primary_10_1016_j_livsci_2014_02_008 crossref_primary_10_1017_S0029665123003750 crossref_primary_10_1186_1471_2318_11_S1_A19 crossref_primary_10_1590_1806_9061_2019_1176 crossref_primary_10_1152_ajpendo_00067_2005 crossref_primary_10_1016_S1262_3636_05_73648_X crossref_primary_10_1007_s00726_009_0347_3 crossref_primary_10_1039_C7FO01181D crossref_primary_10_1371_journal_pone_0130553 crossref_primary_10_1016_j_nut_2009_06_027 crossref_primary_10_3390_nu14173532 crossref_primary_10_5717_jenb_2015_19_1_31 crossref_primary_10_1016_j_cct_2015_06_001 crossref_primary_10_1139_H09_132 crossref_primary_10_3390_nu9101071 crossref_primary_10_1007_s00726_015_2067_1 crossref_primary_10_3390_nu11081771 crossref_primary_10_1093_gerona_gls221 crossref_primary_10_3945_ajcn_110_009043 crossref_primary_10_1017_jns_2023_76 crossref_primary_10_1093_ajcn_87_5_1576S crossref_primary_10_3390_nu11122987 crossref_primary_10_3945_jn_114_198671 crossref_primary_10_1111_j_1753_4887_2007_tb00296_x crossref_primary_10_1186_1743_7075_5_1 crossref_primary_10_3389_fnut_2018_00083 crossref_primary_10_1016_j_chemosphere_2015_08_052 crossref_primary_10_2174_1389200220666181231124439 crossref_primary_10_1007_s13668_020_00318_0 crossref_primary_10_1186_s12986_019_0417_9 crossref_primary_10_1186_s43088_021_00154_3 crossref_primary_10_3109_09637486_2011_573772 crossref_primary_10_1111_1471_0307_12280 crossref_primary_10_11002_kjfp_2015_22_2_218 crossref_primary_10_1371_journal_pone_0084094 crossref_primary_10_3168_jds_S0022_0302_06_72346_3 crossref_primary_10_3390_nu10040507 crossref_primary_10_1016_j_cyto_2017_04_019 crossref_primary_10_1111_j_1753_4887_2007_tb00289_x crossref_primary_10_1093_jn_136_4_958 crossref_primary_10_1136_bjsm_2006_030031 crossref_primary_10_1177_15353702221139189 crossref_primary_10_1371_journal_pone_0084533 crossref_primary_10_1016_j_aquaculture_2014_12_021 crossref_primary_10_3945_ajcn_112_051201 crossref_primary_10_2527_jas_2015_0120 crossref_primary_10_1007_s00726_015_1932_2 crossref_primary_10_3390_ijerph19095145 crossref_primary_10_2527_jas_2008_1703 crossref_primary_10_3389_fnut_2024_1394916 crossref_primary_10_1249_MSS_0000000000000272 crossref_primary_10_1017_S0007114509991310 crossref_primary_10_1519_SSC_0b013e31825663bd crossref_primary_10_1093_nutrit_nuad061 crossref_primary_10_1152_ajpgi_00299_2010 crossref_primary_10_1371_journal_pone_0075998 crossref_primary_10_1016_j_metabol_2007_06_023 crossref_primary_10_2478_abmj_2020_0006 crossref_primary_10_1002_slct_202203665 crossref_primary_10_1186_1550_2783_3_1_7 crossref_primary_10_1016_j_biopha_2022_113390 crossref_primary_10_3390_nu11123016 crossref_primary_10_1093_gerona_63_7_669 crossref_primary_10_4162_nrp_2009_3_3_200 crossref_primary_10_1007_s11802_010_1770_5 crossref_primary_10_1007_s00018_022_04566_x crossref_primary_10_1016_j_nut_2006_12_003 crossref_primary_10_1016_j_appet_2022_106339 crossref_primary_10_2460_javma_247_4_365 crossref_primary_10_1016_j_lfs_2007_04_015 crossref_primary_10_1007_s00726_014_1677_3 crossref_primary_10_1021_acs_langmuir_4c00806 crossref_primary_10_3892_or_2012_1928 crossref_primary_10_1210_jc_2008_2686 crossref_primary_10_1097_MCO_0b013e3282f2a592 crossref_primary_10_3390_nu10121977 crossref_primary_10_1007_s00394_020_02302_4 crossref_primary_10_1016_j_idairyj_2015_02_002 crossref_primary_10_1371_journal_pone_0070130 crossref_primary_10_3945_ajcn_112_038927 crossref_primary_10_1002_j_2617_1619_2018_tb00003_x crossref_primary_10_1017_S0029665115000130 crossref_primary_10_1152_ajpendo_00488_2005 crossref_primary_10_1007_s10517_009_0631_y crossref_primary_10_1016_j_jasrep_2024_104383 crossref_primary_10_3390_nu16111718 crossref_primary_10_1200_JCO_2016_68_3292 crossref_primary_10_1093_jas_skab323 crossref_primary_10_1186_1550_2783_7_7 crossref_primary_10_1007_s13402_022_00706_4 crossref_primary_10_1111_j_1525_139X_2010_00705_x crossref_primary_10_1111_anu_12077 crossref_primary_10_2460_javma_247_4_375 crossref_primary_10_1042_BSR20160036 crossref_primary_10_1186_s12970_017_0193_8 crossref_primary_10_1186_s12970_018_0242_y crossref_primary_10_5507_bp_2014_034 crossref_primary_10_3390_cancers12071880 crossref_primary_10_1017_S0007114521001550 |
| Cites_doi | 10.1097/00075197-200401000-00008 10.1093/jn/131.4.1171 10.1042/bj1920719 10.1042/bj2100669 10.1093/jn/132.1.95 10.1152/ajplegacy.1974.226.3.528 10.1007/BF01115004 10.1042/bj2540579 10.1172/JCI109067 10.1016/0026-0495(77)90077-4 10.1093/jn/134.4.968S 10.1172/JCI110066 10.1152/ajpendo.00208.2001 10.1016/S0021-9258(19)42013-9 10.1093/jn/133.4.1198 10.1042/cs0590173 10.1093/jn/129.6.1102 10.1093/jn/134.7.1704 10.1146/annurev.nu.07.070187.002543 10.1016/0304-4165(78)90103-4 10.1093/jn/133.6.2052S 10.2337/diabetes.51.4.928 10.1042/bj2040831 10.1172/JCI108201 10.1016/S0021-9258(19)77202-0 |
| ContentType | Journal Article Conference Proceeding |
| Copyright | 2005 INIST-CNRS |
| Copyright_xml | – notice: 2005 INIST-CNRS |
| DBID | FBQ IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION |
| DOI | 10.1093/jn/135.6.1553s |
| DatabaseName | AGRIS Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Diet & Clinical Nutrition |
| EISSN | 1541-6100 |
| EndPage | 1556 |
| ExternalDocumentID | 10_1093_jn_135_6_1553S 15930468 16892269 US201301001151 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Review |
| GroupedDBID | --- -ET -~X .55 .GJ 0R~ 18M 29L 2WC 34G 39C 3O- 4.4 48X 53G 5GY 5RE 5VS 85S A8Z AABJS AABMN AABZA AACZT AAJQQ AAPGJ AAPQZ AAUQX AAVAP AAWDT AAWTL AAXUO AAYJJ ABBTP ABJNI ABPTD ABPTK ABSAR ABSGY ABWST ACFRR ACGFO ACGOD ACIHN ACIMA ACKIV ACNCT ACUFI ACUTJ ADBBV ADEIU ADGZP ADRTK ADVEK AEAQA AENEX AEQTP AETBJ AETEA AFDAS AFFNX AFFZL AFMIJ AFOFC AFRAH AFXAL AGINJ AGQXC AGUTN AHMBA AIKOY AIMBJ AJEEA ALEEW ALMA_UNASSIGNED_HOLDINGS ALXQX AMRAJ AQDSO AQKUS ASMCH AZQFJ BAWUL BAYMD BCR BCRHZ BES BEYMZ BKOMP BLC BTRTY BYORX C1A CASEJ CDBKE DAKXR DIK DPPUQ DU5 E3Z EBS EIHJH EJD ENERS EX3 F5P F9R FBQ FDB FECEO FLUFQ FOEOM FOTVD FQBLK FRP G8K GAUVT GJXCC GX1 HF~ HZ~ IH2 K-O KBUDW KOP KQ8 KSI KSN L7B MBLQV MHKGH MV1 MVM NHB NHCRO NOMLY NOYVH NVLIB O9- OAUYM OBFPC ODMLO OHT OJZSN OK1 OPAEJ OVD P-O P2P PEA PQQKQ PRG R0Z RHF RHI ROL ROX SV3 TAE TEORI TMA TN5 TNT TR2 TWZ UCJ UHB UKR UPT W2D W8F WH7 WHG WOQ WOW X7M XFK XOL XSW Y6R YBU YHG YKV YQJ YQT YSK ZGI ZHY ZXP ~KM 08R AAPXW AAUGY AFYAG AKALU APJGH H13 IQODW 0SF ADUKH ADVLN AFJKZ AFRQD AGKRT AITUG AKRWK CGR CUY CVF ECM EIF NPM UIG AAYXX CITATION |
| ID | FETCH-LOGICAL-c453t-c087c789debc29e232d91e7a727db6ff308bd6997dd40378f12024cb42df78113 |
| ISSN | 0022-3166 |
| IngestDate | Thu Sep 26 17:50:03 EDT 2024 Sat Sep 28 08:16:01 EDT 2024 Sun Oct 22 16:06:13 EDT 2023 Wed Dec 27 19:15:52 EST 2023 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6S |
| Keywords | Pancreatic hormone Nutrition Leucine Metabolism branched-chain amino acids Insulin Protein Branched chain Regulation(control) Protein synthesis Valine Aminoacid Muscle Isoleucine |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MeetingName | 4th Amino Acid Assessment Workshop |
| MergedId | FETCHMERGED-LOGICAL-c453t-c087c789debc29e232d91e7a727db6ff308bd6997dd40378f12024cb42df78113 |
| OpenAccessLink | https://doi.org/10.1093/jn/135.6.1553s |
| PMID | 15930468 |
| PageCount | 4 |
| ParticipantIDs | crossref_primary_10_1093_jn_135_6_1553S pubmed_primary_15930468 pascalfrancis_primary_16892269 fao_agris_US201301001151 |
| PublicationCentury | 2000 |
| PublicationDate | 2005-06-01 |
| PublicationDateYYYYMMDD | 2005-06-01 |
| PublicationDate_xml | – month: 06 year: 2005 text: 2005-06-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Bethesda, MD |
| PublicationPlace_xml | – name: Bethesda, MD – name: United States |
| PublicationTitle | The Journal of nutrition |
| PublicationTitleAlternate | J Nutr |
| PublicationYear | 2005 |
| Publisher | American Society for Nutritional Sciences |
| Publisher_xml | – name: American Society for Nutritional Sciences |
| References | Mortimore (10.1093/jn/135.6.1553S_bib25) 1987; 7 Anthony (10.1093/jn/135.6.1553S_bib24) 2001; 131 McNurlan (10.1093/jn/135.6.1553S_bib11) 1982; 204 Anthony (10.1093/jn/135.6.1553S_bib19) 2002; 282 Morgan (10.1093/jn/135.6.1553S_bib4) 1971; 246 Buse (10.1093/jn/135.6.1553S_bib2) 1975; 56 Bolster (10.1093/jn/135.6.1553S_bib21) 2004; 134 Kadowaki (10.1093/jn/135.6.1553S_bib23) 2003; 133 Garlick (10.1093/jn/135.6.1553S_bib12) 1980; 192 Li (10.1093/jn/135.6.1553S_bib3) 1978; 544 Mitch (10.1093/jn/135.6.1553S_bib8) 1981; 67 Sapir (10.1093/jn/135.6.1553S_bib7) 1977; 26 Dardevet (10.1093/jn/135.6.1553S_bib16) 2002; 132 Fulks (10.1093/jn/135.6.1553S_bib1) 1975; 250 Garlick (10.1093/jn/135.6.1553S_bib15) 1988; 254 Buse (10.1093/jn/135.6.1553S_bib10) 1979; 11 Anthony (10.1093/jn/135.6.1553S_bib18) 1999; 129 Layman (10.1093/jn/135.6.1553S_bib26) 2004; 134 Rannels (10.1093/jn/135.6.1553S_bib5) 1974; 226 Sherwin (10.1093/jn/135.6.1553S_bib6) 1978; 61 Anthony (10.1093/jn/135.6.1553S_bib20) 2002; 51 Hagenfeldt (10.1093/jn/135.6.1553S_bib9) 1980; 59 Preedy (10.1093/jn/135.6.1553S_bib13) 1986; 6 Garlick (10.1093/jn/135.6.1553S_bib14) 1983; 210 Kimball (10.1093/jn/135.6.1553S_bib22) 2004; 7 Rieu (10.1093/jn/135.6.1553S_bib17) 2003; 133 |
| References_xml | – volume: 7 start-page: 39 year: 2004 ident: 10.1093/jn/135.6.1553S_bib22 article-title: Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin publication-title: Curr. Opin. Clin. Nutr. Metab. Care doi: 10.1097/00075197-200401000-00008 contributor: fullname: Kimball – volume: 131 start-page: 1171 year: 2001 ident: 10.1093/jn/135.6.1553S_bib24 article-title: Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in liver of rats publication-title: J. Nutr. doi: 10.1093/jn/131.4.1171 contributor: fullname: Anthony – volume: 192 start-page: 719 year: 1980 ident: 10.1093/jn/135.6.1553S_bib12 article-title: A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of (3H)phenylalanine publication-title: Biochem. J. doi: 10.1042/bj1920719 contributor: fullname: Garlick – volume: 210 start-page: 669 year: 1983 ident: 10.1093/jn/135.6.1553S_bib14 article-title: The effect of insulin infusion and food intake on muscle protein synthesis in postabsorptive rats publication-title: Biochem. J. doi: 10.1042/bj2100669 contributor: fullname: Garlick – volume: 132 start-page: 95 year: 2002 ident: 10.1093/jn/135.6.1553S_bib16 article-title: Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal publication-title: J. Nutr. doi: 10.1093/jn/132.1.95 contributor: fullname: Dardevet – volume: 226 start-page: 528 year: 1974 ident: 10.1093/jn/135.6.1553S_bib5 article-title: Effects of noncarbohydrate substances on protein synthesis in muscle publication-title: Am J. Physiol. doi: 10.1152/ajplegacy.1974.226.3.528 contributor: fullname: Rannels – volume: 6 start-page: 177 year: 1986 ident: 10.1093/jn/135.6.1553S_bib13 article-title: The response of muscle protein synthesis to nutrient intake in postabsorptive rats: the role of insulin and amino acids publication-title: Biosci. Rep. doi: 10.1007/BF01115004 contributor: fullname: Preedy – volume: 254 start-page: 579 year: 1988 ident: 10.1093/jn/135.6.1553S_bib15 article-title: Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin publication-title: Biochem J. doi: 10.1042/bj2540579 contributor: fullname: Garlick – volume: 61 start-page: 1471 year: 1978 ident: 10.1093/jn/135.6.1553S_bib6 article-title: Effect of starvation on the turnover and metabolic response to leucine publication-title: J. Clin. Invest. doi: 10.1172/JCI109067 contributor: fullname: Sherwin – volume: 11 start-page: 289 year: 1979 ident: 10.1093/jn/135.6.1553S_bib10 article-title: In vitro effect of branched chain amino acids on the ribosomal cycle in muscles of fasted rats publication-title: Horm. Metab. Res. contributor: fullname: Buse – volume: 26 start-page: 301 year: 1977 ident: 10.1093/jn/135.6.1553S_bib7 article-title: Nitrogen sparing induced in starvation by infusion of branched chain ketoacids publication-title: Metab. Clin. Exp. doi: 10.1016/0026-0495(77)90077-4 contributor: fullname: Sapir – volume: 134 start-page: 968S year: 2004 ident: 10.1093/jn/135.6.1553S_bib26 article-title: Dietary protein impact on glycemic control during weight loss publication-title: J Nutr. doi: 10.1093/jn/134.4.968S contributor: fullname: Layman – volume: 67 start-page: 553 year: 1981 ident: 10.1093/jn/135.6.1553S_bib8 article-title: Nitrogen sparing induced by leucine compared with that induced by its keto analogue, μ-ketoisocaproate, in fasting obese man publication-title: J. Clin. Invest. doi: 10.1172/JCI110066 contributor: fullname: Mitch – volume: 282 start-page: E1092 year: 2002 ident: 10.1093/jn/135.6.1553S_bib19 article-title: Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00208.2001 contributor: fullname: Anthony – volume: 250 start-page: 290 year: 1975 ident: 10.1093/jn/135.6.1553S_bib1 article-title: Effects of insulin, glucose and amino acids on protein turnover in rat diaphragms publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)42013-9 contributor: fullname: Fulks – volume: 133 start-page: 1198 year: 2003 ident: 10.1093/jn/135.6.1553S_bib17 article-title: Leucine-supplemented meal feeding for ten days beneficially affects postprandial muscle protein synthesis in old rats publication-title: J. Nutr. doi: 10.1093/jn/133.4.1198 contributor: fullname: Rieu – volume: 59 start-page: 173 year: 1980 ident: 10.1093/jn/135.6.1553S_bib9 article-title: Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects publication-title: Clin. Sci. doi: 10.1042/cs0590173 contributor: fullname: Hagenfeldt – volume: 129 start-page: 1102 year: 1999 ident: 10.1093/jn/135.6.1553S_bib18 article-title: Leucine supplementation enhances skeletal muscle recovery in rats following exercise publication-title: J. Nutr. doi: 10.1093/jn/129.6.1102 contributor: fullname: Anthony – volume: 134 start-page: 1704 year: 2004 ident: 10.1093/jn/135.6.1553S_bib21 article-title: Leucine regulates translation initiation in rat skeletal muscle via enhanced elF4G phosphorylation publication-title: J. Nutr. doi: 10.1093/jn/134.7.1704 contributor: fullname: Bolster – volume: 7 start-page: 539 year: 1987 ident: 10.1093/jn/135.6.1553S_bib25 article-title: Intracellular protein catabolism and its control during nutrient deprivation and supply publication-title: Ann. Rev. Nutr. doi: 10.1146/annurev.nu.07.070187.002543 contributor: fullname: Mortimore – volume: 544 start-page: 351 year: 1978 ident: 10.1093/jn/135.6.1553S_bib3 article-title: Influence of amino acid availability on protein turnover in perfused skeletal muscle publication-title: Biochim. Biophys. Acta. doi: 10.1016/0304-4165(78)90103-4 contributor: fullname: Li – volume: 133 start-page: 2052S year: 2003 ident: 10.1093/jn/135.6.1553S_bib23 article-title: Amino acids as regulators of proteolysis publication-title: J. Nutr. doi: 10.1093/jn/133.6.2052S contributor: fullname: Kadowaki – volume: 51 start-page: 928 year: 2002 ident: 10.1093/jn/135.6.1553S_bib20 article-title: Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation publication-title: Diabetes doi: 10.2337/diabetes.51.4.928 contributor: fullname: Anthony – volume: 204 start-page: 831 year: 1982 ident: 10.1093/jn/135.6.1553S_bib11 article-title: Failure of leucine to stimulate protein synthesis in vivo publication-title: Biochem. J. doi: 10.1042/bj2040831 contributor: fullname: McNurlan – volume: 56 start-page: 1250 year: 1975 ident: 10.1093/jn/135.6.1553S_bib2 article-title: Leucine: a possible regulator of protein turnover in muscle publication-title: J. Clin. Invest. doi: 10.1172/JCI108201 contributor: fullname: Buse – volume: 246 start-page: 2152 year: 1971 ident: 10.1093/jn/135.6.1553S_bib4 article-title: Regulation of protein synthesis in heart muscle. I. Effect of amino acid levels on protein synthesis publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)77202-0 contributor: fullname: Morgan |
| SSID | ssj0001498 |
| Score | 2.3181586 |
| SecondaryResourceType | review_article |
| Snippet | Studies both in vivo and in vitro have shown that leucine at a very high dose can stimulate muscle protein synthesis, an effect that is enhanced in vivo by... |
| SourceID | crossref pubmed pascalfrancis fao |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 1553 |
| SubjectTerms | Amino Acids, Branched-Chain - metabolism Amino Acids, Branched-Chain - physiology Animals Biological and medical sciences Dose-Response Relationship, Drug Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Glucose - metabolism Humans Insulin - blood Insulin - metabolism Insulin Secretion leucine Leucine - pharmacology Leucine - physiology literature reviews liver mechanism of action Muscle Proteins - biosynthesis Muscle Proteins - metabolism Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism nutrient intake protein degradation protein metabolism protein synthesis Rats signal transduction skeletal muscle Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| Title | Role of Leucine in the Regulation of Protein Metabolism |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/15930468 |
| Volume | 135 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Rb9MwELbY9sIbjMEyYPIDgqd0Sew4tniaNtCgaELrKvYWJbaDqLoUbdkLv567xHHSUgnBS9Tastvene_O9XefCXmT6DTSLMlCKwsecq5lKCvGQ12VlYEQVyamRfleios5_3yT3gzXHbXVJU050b-21pX8j1ahDfSKVbL_oFk_KTTAa9AvPEHD8PxTx9tDja_sWnaQDMetv2kJPYhwaR_wJL1HN951N9G7pLHlbICeW9uAaSx7ckFE55xeffl0NvWAXneY1P9bkA6ophFAHz3HCBN62X83xz-C-O2xz0S8fywcYbVzkzyGTWcUrfnRjnfEGYyYjdwiXk40CrHwVmx13x211QIDFMw2ERMceD-Eqv54fiOCeVxhLKSCfFLtkL2EqRS83N7p9Orb1Mdm2A9Kzx8Pv8nTeLKTRX0y-sy1NGWnKlYImi3uYd1U3YUnG9uQNh25fkIOhkJN-tXbxVPyyNb7JDgHmdO31FG-LqmX_DPyHoyBojHQVUWdMdAfNW2w2RsDdjpjoIMxHJD5xw_XZxehuz8j1DxlTagjmelMKmNLnSgLubNRsc0KSFmx-LJikSyNUCozhkcsk1WcQMamS56YCguQ2XOyW69qe0ioKFIbRzoxMIRDjl0YwQoNyWEZ43LOAvKuF1f-s6NJyTt4A8sXdQ6CzUWOgp0F5BCkmRffIYbl81mCJ-dxuzGJA3K8JuJhJqfWgLzoZD70pAqP9uXR34a-JI-H5fCK7DZ3D_Y1pJNNeexs5Dd9uXMO |
| link.rule.ids | 310,311,315,786,790,795,796,23958,23959,25170,27957,27958 |
| linkProvider | Library Specific Holdings |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=proceeding&rft.title=The+Journal+of+nutrition&rft.atitle=The+role+of+leucine+in+the+regulation+of+protein+metabolism&rft.au=GARLICK%2C+Peter+J&rft.date=2005-06-01&rft.pub=American+Society+for+Nutritional+Sciences&rft.issn=0022-3166&rft.eissn=1541-6100&rft.volume=135&rft.issue=6S&rft.spage=1553&rft.epage=1556&rft_id=info:doi/10.1093%2Fjn%2F135.6.1553s&rft.externalDBID=n%2Fa&rft.externalDocID=16892269 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3166&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3166&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3166&client=summon |