Keap1–Nrf2 regulated redox signaling in utero: Priming of disease susceptibility in offspring

• Published in: Free radical biology & medicine Vol. 88; no. Pt B; pp. 212 - 220
• Main Authors: Chapple, Sarah J., Puszyk, William M., Mann, Giovanni E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2015
• Subjects: Animals; Cardiovascular disease; Developmental priming; Diabetes, Gestational; Disease Susceptibility - metabolism; Epigenetics; Female; Fetal Development - physiology; Fetal endothelial cells; Fetal programing; Gestational diabetes; Humans; Intracellular Signaling Peptides and Proteins - metabolism; Intrauterine growth restriction; Keap1–Nrf2; NF-E2-Related Factor 2 - metabolism; Oxidation-Reduction; Oxidative Stress - physiology; Pre-eclampsia; Pregnancy; Pregnancy Complications - metabolism; Prenatal Exposure Delayed Effects - metabolism; Redox signaling; Signal Transduction - physiology; Type 2 diabetes; NADPH; Type 2 diabetes; NQO1; CE; Developmental priming; Cardiovascular disease; Pre-eclampsia; Fetal programing; Redox signaling; SOD1; GCL; GDM; Intrauterine growth restriction; Fetal endothelial cells; IUGR; Nrf2; PE; Keap1–Nrf2; RNS; ROS; Epigenetics; SFN; Gestational diabetes
• ISSN: 0891-5849; 1873-4596
• DOI: 10.1016/j.freeradbiomed.2015.08.001

Intrauterine exposure to gestational diabetes, pre-eclampsia or intrauterine growth restriction alters the redox status of the developing fetus. Such pregnancy-related diseases in most cases do not have a readily identifiable genetic cause, and epigenetic 'priming' mechanisms in utero may...