Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair

The beneficial functions of mesenchymal stem cells (MSCs) decline with age, limiting their therapeutic efficacy for myocardial infarction (MI). Macrophage migration inhibitory factor (MIF) promotes cell proliferation and survival. We investigated whether MIF overexpression could rejuvenate aged MSCs...

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Bibliographic Details
Published inAging (Albany, NY.) Vol. 11; no. 24; pp. 12641 - 12660
Main Authors Zhang, Yuelin, Zhu, Wenwu, He, Haiwei, Fan, Baohan, Deng, Rui, Hong, Yimei, Liang, Xiaoting, Zhao, Hongyan, Li, Xin, Zhang, Fengxiang
Format Journal Article
LanguageEnglish
Published United States Impact Journals 27.12.2019
Subjects
Research Paper
senescence
macrophage migration inhibitory factor
rejuvenation
mesenchymal stem cells
myocardial infarction
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