Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcification

• Published in: Aging (Albany, NY.) Vol. 9; no. 3; pp. 778 - 789
• Main Authors: Alique, Matilde, Ruíz-Torres, María Piedad, Bodega, Guillermo, Noci, María Victoria, Troyano, Nuria, Bohórquez, Lourdes, Luna, Carlos, Luque, Rafael, Carmona, Andrés, Carracedo, Julia, Ramírez, Rafael
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 08.03.2017
• Subjects: Aged; Aged, 80 and over; Aging - pathology; Calcium - metabolism; Cell-Derived Microparticles - pathology; Cells, Cultured; Cellular Senescence; Endothelial Cells - pathology; Humans; Research Paper; Vascular Calcification - metabolism; Vascular Calcification - pathology; Young Adult; senescence; endothelial cells; aging; microvesicles; vascular smooth muscle cells; vascular calcification

Vascular calcification is commonly seen in elderly people, though it can also appear in middle-aged subjects affected by premature vascular aging. The aim of this work is to test the involvement of microvesicles (MVs) produced by senescent endothelial cells (EC) and from plasma of elderly people in...