Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcification
Vascular calcification is commonly seen in elderly people, though it can also appear in middle-aged subjects affected by premature vascular aging. The aim of this work is to test the involvement of microvesicles (MVs) produced by senescent endothelial cells (EC) and from plasma of elderly people in...
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| Published in | Aging (Albany, NY.) Vol. 9; no. 3; pp. 778 - 789 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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08.03.2017
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| Abstract | Vascular calcification is commonly seen in elderly people, though it can also appear in middle-aged subjects affected by premature vascular aging. The aim of this work is to test the involvement of microvesicles (MVs) produced by senescent endothelial cells (EC) and from plasma of elderly people in vascular calcification. The present work shows that MVs produced by senescent cultured ECs, plus those found in the plasma of elderly subjects, promote calcification in vascular smooth muscle cells. Only MVs from senescent ECs, and from elderly subjects' plasma, induced calcification. This ability correlated with these types of MVs' carriage of: a) increased quantities of annexins (which might act as nucleation sites for calcification), b) increased quantities of bone-morphogenic protein, and c) larger Ca contents. The MVs of senescent, cultured ECs, and those present in the plasma of elderly subjects, promote vascular calcification. The present results provide mechanistic insights into the observed increase in vascular calcification-related diseases in the elderly, and in younger patients with premature vascular aging, paving the way towards novel therapeutic strategies. |
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| AbstractList | Vascular calcification is commonly seen in elderly people, though it can also appear in middle-aged subjects affected by premature vascular aging. The aim of this work is to test the involvement of microvesicles (MVs) produced by senescent endothelial cells (EC) and from plasma of elderly people in vascular calcification. The present work shows that MVs produced by senescent cultured ECs, plus those found in the plasma of elderly subjects, promote calcification in vascular smooth muscle cells. Only MVs from senescent ECs, and from elderly subjects' plasma, induced calcification. This ability correlated with these types of MVs' carriage of: a) increased quantities of annexins (which might act as nucleation sites for calcification), b) increased quantities of bone-morphogenic protein, and c) larger Ca contents. The MVs of senescent, cultured ECs, and those present in the plasma of elderly subjects, promote vascular calcification. The present results provide mechanistic insights into the observed increase in vascular calcification-related diseases in the elderly, and in younger patients with premature vascular aging, paving the way towards novel therapeutic strategies.Vascular calcification is commonly seen in elderly people, though it can also appear in middle-aged subjects affected by premature vascular aging. The aim of this work is to test the involvement of microvesicles (MVs) produced by senescent endothelial cells (EC) and from plasma of elderly people in vascular calcification. The present work shows that MVs produced by senescent cultured ECs, plus those found in the plasma of elderly subjects, promote calcification in vascular smooth muscle cells. Only MVs from senescent ECs, and from elderly subjects' plasma, induced calcification. This ability correlated with these types of MVs' carriage of: a) increased quantities of annexins (which might act as nucleation sites for calcification), b) increased quantities of bone-morphogenic protein, and c) larger Ca contents. The MVs of senescent, cultured ECs, and those present in the plasma of elderly subjects, promote vascular calcification. The present results provide mechanistic insights into the observed increase in vascular calcification-related diseases in the elderly, and in younger patients with premature vascular aging, paving the way towards novel therapeutic strategies. Vascular calcification is commonly seen in elderly people, though it can also appear in middle-aged subjects affected by premature vascular aging. The aim of this work is to test the involvement of microvesicles (MVs) produced by senescent endothelial cells (EC) and from plasma of elderly people in vascular calcification. The present work shows that MVs produced by senescent cultured ECs, plus those found in the plasma of elderly subjects, promote calcification in vascular smooth muscle cells. Only MVs from senescent ECs, and from elderly subjects' plasma, induced calcification. This ability correlated with these types of MVs' carriage of: a) increased quantities of annexins (which might act as nucleation sites for calcification), b) increased quantities of bone-morphogenic protein, and c) larger Ca contents. The MVs of senescent, cultured ECs, and those present in the plasma of elderly subjects, promote vascular calcification. The present results provide mechanistic insights into the observed increase in vascular calcification-related diseases in the elderly, and in younger patients with premature vascular aging, paving the way towards novel therapeutic strategies. |
| Author | Ramírez, Rafael Luque, Rafael Ruíz-Torres, María Piedad Luna, Carlos Noci, María Victoria Bohórquez, Lourdes Carracedo, Julia Bodega, Guillermo Alique, Matilde Troyano, Nuria Carmona, Andrés |
| AuthorAffiliation | 7 Institute of Investigation, Hospital 12 de Octubre, Madrid, Spain 4 Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía/Universidad de Córdoba, Córdoba, Andalucía, Spain 1 Departamento de Biología de Sistemas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain 2 Departamento de Biomedicina y Biotecnología, Facultad de Biología, Química y Ciencias Ambientales, Universidad de Alcalá. Alcalá de Henares, Madrid, Spain 3 Unidad de Anestesia, Hospital Universitario Reina Sofía/Universidad de Córdoba, Córdoba, Andalucía, Spain 5 Departamento de Química Orgánica, Universidad de Córdoba, Edificio Marie Curie (C-3), Carretera Nacional IV-A, Km 396, E14014, Córdoba, Andalucía, Spain 6 Departamento de Fisiología Animal (II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain |
| AuthorAffiliation_xml | – name: 3 Unidad de Anestesia, Hospital Universitario Reina Sofía/Universidad de Córdoba, Córdoba, Andalucía, Spain – name: 1 Departamento de Biología de Sistemas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain – name: 7 Institute of Investigation, Hospital 12 de Octubre, Madrid, Spain – name: 6 Departamento de Fisiología Animal (II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain – name: 5 Departamento de Química Orgánica, Universidad de Córdoba, Edificio Marie Curie (C-3), Carretera Nacional IV-A, Km 396, E14014, Córdoba, Andalucía, Spain – name: 2 Departamento de Biomedicina y Biotecnología, Facultad de Biología, Química y Ciencias Ambientales, Universidad de Alcalá. Alcalá de Henares, Madrid, Spain – name: 4 Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía/Universidad de Córdoba, Córdoba, Andalucía, Spain |
| Author_xml | – sequence: 1 givenname: Matilde surname: Alique fullname: Alique, Matilde organization: Departamento de Biología de Sistemas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain, These authors contributed equally to this paper – sequence: 2 givenname: María Piedad surname: Ruíz-Torres fullname: Ruíz-Torres, María Piedad organization: Departamento de Biología de Sistemas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain, These authors contributed equally to this paper – sequence: 3 givenname: Guillermo surname: Bodega fullname: Bodega, Guillermo organization: Departamento de Biomedicina y Biotecnología, Facultad de Biología, Química y Ciencias Ambientales, Universidad de Alcalá. Alcalá de Henares, Madrid, Spain – sequence: 4 givenname: María Victoria surname: Noci fullname: Noci, María Victoria organization: Unidad de Anestesia, Hospital Universitario Reina Sofía/Universidad de Córdoba, Córdoba, Andalucía, Spain, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía/Universidad de Córdoba, Córdoba, Andalucía, Spain – sequence: 5 givenname: Nuria surname: Troyano fullname: Troyano, Nuria organization: Departamento de Biología de Sistemas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain – sequence: 6 givenname: Lourdes surname: Bohórquez fullname: Bohórquez, Lourdes organization: Departamento de Biología de Sistemas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain – sequence: 7 givenname: Carlos surname: Luna fullname: Luna, Carlos organization: Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía/Universidad de Córdoba, Córdoba, Andalucía, Spain – sequence: 8 givenname: Rafael surname: Luque fullname: Luque, Rafael organization: Departamento de Química Orgánica, Universidad de Córdoba, Edificio Marie Curie (C-3), Carretera Nacional IV-A, Km 396, E14014, Córdoba, Andalucía, Spain – sequence: 9 givenname: Andrés surname: Carmona fullname: Carmona, Andrés organization: Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía/Universidad de Córdoba, Córdoba, Andalucía, Spain – sequence: 10 givenname: Julia surname: Carracedo fullname: Carracedo, Julia organization: Departamento de Fisiología Animal (II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain, Institute of Investigation, Hospital 12 de Octubre, Madrid, Spain, These senior authors contributed equally to this paper – sequence: 11 givenname: Rafael surname: Ramírez fullname: Ramírez, Rafael organization: Departamento de Biología de Sistemas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain, These senior authors contributed equally to this paper |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28278131$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.ijcard.2013.01.231 10.1038/nrneph.2013.176 10.1161/CIRCRESAHA.110.238808 10.1161/CIRCRESAHA.113.301036 10.1096/fj.14-249706 10.1161/01.CIR.0000013836.85741.17 10.1161/CIRCULATIONAHA.110.009118 10.1016/j.tcm.2014.10.021 10.1111/j.1538-7836.2008.03200.x 10.1016/S0735-1097(01)01737-5 10.1016/j.exger.2013.04.004 10.1016/j.jsb.2008.03.003 10.1093/gerona/glp187 10.1016/j.yjmcc.2015.01.021 10.1161/01.RES.00000175571.53833.6c 10.1016/j.atherosclerosis.2007.11.031 10.1016/j.exger.2012.11.017 10.3389/fphys.2015.00395 10.1161/CIRCRESAHA.113.300858 10.1161/CIRCRESAHA.116.305012 10.1161/ATVBAHA.112.300128 10.1161/CIRCULATIONAHA.110.007021 10.1016/S0022-4804(66)80013-6 10.1007/s11926-003-0071-z 10.1101/gad.235184.113 10.1007/s00223-013-9784-9 10.3402/jev.v4.27066 |
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| Keywords | senescence endothelial cells aging microvesicles vascular smooth muscle cells vascular calcification |
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| References | Leopold (3) 2015; 2 Lesniewski (9) 2015; 8 Giachelli (4) 2008; 19 Saab (19) 2005; 9 Shanahan (2) 2013; 9 Ramirez (13) 2015; 6 McKee (23) 2008; 16 Komuro (8) 2002; 10 Dignat-George (28) 2009; 7 Raggi (1) 2002; 3 Robinson (21) 1966; 6 Nanci (22) 2013; 9 Grillari (12) 2013; 4 Boddaert (15) 2010; 6 Muller (6) 2015; 11 Shanahan (7) 2011; 10 Boulanger (11) 2014; 11 Ramírez (26) 2013; 4 Fuster (17) 2011; 12 Carracedo (10) 2015; 2 Anderson (20) 2003; 5 Aikawa (24) 2013; 3 Fais (5) 2015; 4 de Kleijn (14) 2013; 16 Aikawa (25) 2013; 11 Fuster (18) 2011; 12 Narita (16) 2014; 2 Erusalimsky (27) 2000; 11 11927518 - Circulation. 2002 Apr 2;105(13):1541-4 25435520 - Trends Cardiovasc Med. 2015 May;25(4):267-74 11017877 - J Cell Sci. 2000 Oct;113 ( Pt 20):3613-22 21566214 - Circ Res. 2011 Jun 24;109(1):e1-12 12744815 - Curr Rheumatol Rep. 2003 Jun;5(3):222-6 23484740 - Int J Cardiol. 2013 Oct 3;168(3):2358-63 16037577 - Circ Res. 2005 Jul 22;97(2):105-14 23283304 - Exp Gerontol. 2013 Jul;48(7):626-33 5906917 - J Surg Res. 1966 Apr;6(4):171-9 25655936 - J Mol Cell Cardiol. 2015 Dec;89(Pt B):122-35 23624226 - Exp Gerontol. 2013 Aug;48(8):766-73 24436430 - Circ Res. 2014 Jan 17;114(2):345-53 21502583 - Circulation. 2011 Apr 19;123(15):1650-60 24018414 - Nat Rev Nephrol. 2013 Nov;9(11):661-70 18424074 - J Struct Biol. 2008 Jun;162(3):468-79 18983485 - J Thromb Haemost. 2009 Jan;7(1):190-7 25979354 - J Extracell Vesicles. 2015 May 14;4:27066 25711438 - Circ Res. 2015 Apr 10;116(8):1312-23 21537006 - Circulation. 2011 May 3;123(17):1900-10 24449267 - Genes Dev. 2014 Jan 15;28(2):99-114 23616621 - Circ Res. 2013 Jun 21;113(1):72-7 23766262 - Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1753-8 19942591 - J Gerontol A Biol Sci Med Sci. 2010 Apr;65(4):414-20 11788211 - J Am Coll Cardiol. 2002 Jan 16;39(2):225-30 26733886 - Front Physiol. 2015 Dec 22;6:395 24077874 - Calcif Tissue Int. 2013 Oct;93(4):382-96 18179800 - Atherosclerosis. 2008 Aug;199(2):271-7 25342130 - FASEB J. 2015 Jan;29(1):173-81 |
| References_xml | – volume: 16 start-page: 2358 year: 2013 ident: 14 article-title: Microvesicle protein levels are associated with increased risk for future vascular events and mortality in patients with clinically manifest vascular disease. publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2013.01.231 – volume: 9 start-page: 661 year: 2013 ident: 2 article-title: Mechanisms of vascular calcification in CKD-evidence for premature ageing? publication-title: Nat Rev Nephrol doi: 10.1038/nrneph.2013.176 – volume: 10 start-page: e1 year: 2011 ident: 7 article-title: Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization. publication-title: Circ Res doi: 10.1161/CIRCRESAHA.110.238808 – volume: 11 start-page: 3613 year: 2000 ident: 27 article-title: Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. publication-title: J Cell Sci – volume: 11 start-page: 72 year: 2013 ident: 25 article-title: Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques. publication-title: Circ Res doi: 10.1161/CIRCRESAHA.113.301036 – volume: 2 start-page: 173 year: 2015 ident: 10 article-title: Endothelial microparticles mediate inflammation-induced vascular calcification. publication-title: FASEB J doi: 10.1096/fj.14-249706 – volume: 10 start-page: 1541 year: 2002 ident: 8 article-title: Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. publication-title: Circulation doi: 10.1161/01.CIR.0000013836.85741.17 – volume: 12 start-page: 1900 year: 2011 ident: 18 article-title: Cellular senescence, vascular disease, and aging: part 2 of a 2-part review: clinical vascular disease in the elderly. publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.110.009118 – volume: 2 start-page: 267 year: 2015 ident: 3 article-title: Vascular calcification: mechanisms of vascular smooth muscle cell calcification. publication-title: Trends Cardiovasc Med doi: 10.1016/j.tcm.2014.10.021 – volume: 7 start-page: 190 year: 2009 ident: 28 article-title: Standardization of platelet-derived microparticle counting using calibrated beads and a Cytomics FC500 routine flow cytometer: a first step towards multicenter studies? publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2008.03200.x – volume: 3 start-page: 225 year: 2002 ident: 1 article-title: High coronary artery calcium scores pose an extremely elevated risk for hard events. publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(01)01737-5 – volume: 4 start-page: 766 year: 2013 ident: 26 article-title: Cellular senescence determines endothelial cell damage induced by uremia. publication-title: Exp Gerontol doi: 10.1016/j.exger.2013.04.004 – volume: 16 start-page: 468 year: 2008 ident: 23 article-title: Intracellular precipitation of hydroxyapatite mineral and implications for pathologic calcification. publication-title: J Struct Biol doi: 10.1016/j.jsb.2008.03.003 – volume: 6 start-page: 414 year: 2010 ident: 15 article-title: Circulating microparticles and procoagulant activity in elderly patients. publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/glp187 – volume: 8 start-page: 122 year: 2015 ident: 9 article-title: Cellular and molecular biology of aging endothelial cells. publication-title: J Mol Cell Cardiol doi: 10.1016/j.yjmcc.2015.01.021 – volume: 9 start-page: 105 year: 2005 ident: 19 article-title: Bone morphogenetic proteins in vascular calcification. publication-title: Circ Res doi: 10.1161/01.RES.00000175571.53833.6c – volume: 19 start-page: 271 year: 2008 ident: 4 article-title: BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells. publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2007.11.031 – volume: 4 start-page: 626 year: 2013 ident: 12 article-title: Secretion of microvesicular miRNAs in cellular and organismal aging. publication-title: Exp Gerontol doi: 10.1016/j.exger.2012.11.017 – volume: 6 start-page: 395 year: 2015 ident: 13 article-title: TNFα-damaged-HUVEC microparticles modify endothelial progenitor cell functional activity. publication-title: Front Physiol doi: 10.3389/fphys.2015.00395 – volume: 11 start-page: 345 year: 2014 ident: 11 article-title: Microvesicles as cell-cell messengers in cardiovascular diseases. publication-title: Circ Res doi: 10.1161/CIRCRESAHA.113.300858 – volume: 11 start-page: 1312 year: 2015 ident: 6 article-title: Vascular smooth muscle cell calcification is mediated by regulated exosome secretion. publication-title: Circ Res doi: 10.1161/CIRCRESAHA.116.305012 – volume: 3 start-page: 1753 year: 2013 ident: 24 article-title: Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification. publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.112.300128 – volume: 12 start-page: 1650 year: 2011 ident: 17 article-title: Cellular senescence, vascular disease, and aging: Part 1 of a 2-part review. publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.110.007021 – volume: 6 start-page: 171 year: 1966 ident: 21 article-title: Intracellular calcification occurring in a transplanted human tumor. publication-title: J Surg Res doi: 10.1016/S0022-4804(66)80013-6 – volume: 5 start-page: 222 year: 2003 ident: 20 article-title: Matrix vesicles and calcification. publication-title: Curr Rheumatol Rep doi: 10.1007/s11926-003-0071-z – volume: 2 start-page: 99 year: 2014 ident: 16 article-title: Cellular senescence and its effector programs. publication-title: Genes Dev doi: 10.1101/gad.235184.113 – volume: 9 start-page: 382 year: 2013 ident: 22 article-title: A review of phosphate mineral nucleation in biology and geobiology. publication-title: Calcif Tissue Int doi: 10.1007/s00223-013-9784-9 – volume: 4 start-page: 27066 year: 2015 ident: 5 article-title: Biological properties of extracellular vesicles and their physiological functions. publication-title: J Extracell Vesicles doi: 10.3402/jev.v4.27066 – reference: 25435520 - Trends Cardiovasc Med. 2015 May;25(4):267-74 – reference: 24077874 - Calcif Tissue Int. 2013 Oct;93(4):382-96 – reference: 12744815 - Curr Rheumatol Rep. 2003 Jun;5(3):222-6 – reference: 11017877 - J Cell Sci. 2000 Oct;113 ( Pt 20):3613-22 – reference: 18179800 - Atherosclerosis. 2008 Aug;199(2):271-7 – reference: 24436430 - Circ Res. 2014 Jan 17;114(2):345-53 – reference: 21566214 - Circ Res. 2011 Jun 24;109(1):e1-12 – reference: 23283304 - Exp Gerontol. 2013 Jul;48(7):626-33 – reference: 25342130 - FASEB J. 2015 Jan;29(1):173-81 – reference: 5906917 - J Surg Res. 1966 Apr;6(4):171-9 – reference: 19942591 - J Gerontol A Biol Sci Med Sci. 2010 Apr;65(4):414-20 – reference: 25655936 - J Mol Cell Cardiol. 2015 Dec;89(Pt B):122-35 – reference: 18983485 - J Thromb Haemost. 2009 Jan;7(1):190-7 – reference: 23484740 - Int J Cardiol. 2013 Oct 3;168(3):2358-63 – reference: 24018414 - Nat Rev Nephrol. 2013 Nov;9(11):661-70 – reference: 11788211 - J Am Coll Cardiol. 2002 Jan 16;39(2):225-30 – reference: 11927518 - Circulation. 2002 Apr 2;105(13):1541-4 – reference: 23624226 - Exp Gerontol. 2013 Aug;48(8):766-73 – reference: 25711438 - Circ Res. 2015 Apr 10;116(8):1312-23 – reference: 25979354 - J Extracell Vesicles. 2015 May 14;4:27066 – reference: 21502583 - Circulation. 2011 Apr 19;123(15):1650-60 – reference: 21537006 - Circulation. 2011 May 3;123(17):1900-10 – reference: 16037577 - Circ Res. 2005 Jul 22;97(2):105-14 – reference: 24449267 - Genes Dev. 2014 Jan 15;28(2):99-114 – reference: 26733886 - Front Physiol. 2015 Dec 22;6:395 – reference: 23616621 - Circ Res. 2013 Jun 21;113(1):72-7 – reference: 23766262 - Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1753-8 – reference: 18424074 - J Struct Biol. 2008 Jun;162(3):468-79 |
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| Snippet | Vascular calcification is commonly seen in elderly people, though it can also appear in middle-aged subjects affected by premature vascular aging. The aim of... |
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| SubjectTerms | Aged Aged, 80 and over Aging - pathology Calcium - metabolism Cell-Derived Microparticles - pathology Cells, Cultured Cellular Senescence Endothelial Cells - pathology Humans Research Paper Vascular Calcification - metabolism Vascular Calcification - pathology Young Adult |
| Title | Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcification |
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