The protective effects of sumatriptan on vincristine - induced peripheral neuropathy in a rat model

• Published in: Neurotoxicology (Park Forest South) Vol. 67; pp. 279 - 286
• Main Authors: Khalilzadeh, Mina, Panahi, Ghodratollah, Rashidian, Amir, Hadian, Mohammad Reza, Abdollahi, Alireza, Afshari, Khashayar, Shakiba, Saeed, Norouzi-Javidan, Abbas, Rahimi, Nastaran, Momeny, Majid, Dehpour, Ahmad Reza
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2018; Elsevier BV
• Subjects: Body weight; Body weight loss; Caspase; Caspase-3; Chemotherapy; Headache; IL-1β; Immunomodulation; Inflammation; Interleukins; Migraine; Mortality; Motors; Nerve conduction; Neuroprotection; Neuroprotective; NF- B; Peripheral neuropathy; Proteins; Rat; Receptor mechanisms; Receptors; Reverse transcription; Rodents; Serotonin; Sumatriptan; Toxicity; Tumor necrosis factor-α; Vincristine; Weight loss; Neuroprotective; Rat; Peripheral neuropathy; NF- B; Sumatriptan; Vincristine; NF-B

•Vincristine administration induced peripheral neuropathy.•NF-<kappa > B is involved in vincristine-induced neuropathy.•Sumatriptan exerts anti-inflammatory properties through the release of CGRP and SP.•Sumatriptan could be a pretreatment of neuropathy in chemotherapy. Clinical use of vincris...