The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive

• Published in: Journal of rheumatology Vol. 42; no. 3; p. 363
• Main Authors: Orlowsky, Eric W, Kraus, Virginia Byers
• Format: Journal Article
• Language: English
• Published: Canada 01.03.2015
• Subjects: Humans; Immunity, Innate; Inflammation - immunology; Inflammation - pathology; Osteoarthritis - immunology; Osteoarthritis - pathology; Synovial Membrane - immunology; Synovial Membrane - pathology; COMPLEMENT; OSTEOARTHRITIS; MACROPHAGES; INNATE IMMUNITY

Although osteoarthritis (OA) has existed since the dawn of humanity, its pathogenesis remains poorly understood. OA is no longer considered a "wear and tear" condition but rather one driven by proteases where chronic low-grade inflammation may play a role in perpetuating proteolytic activi...