A microfluidic device with 3-d hydrogel villi scaffold to simulate intestinal absorption

• Published in: Journal of nanoscience and nanotechnology Vol. 13; no. 11; p. 7220
• Main Authors: Kim, Si Hyeon, Lee, Jung Woo, Choi, Inwook, Kim, Young-Chan, Lee, Jong Bum, Sung, Jong Hwan
• Format: Journal Article
• Language: English
• Published: United States 01.11.2013
• Subjects: Biological Assay - instrumentation; Biomimetic Materials - chemical synthesis; Biomimetic Materials - chemistry; Biomimetics - instrumentation; Biomimetics - methods; Caco-2 Cells; Diffusion; Drug Evaluation, Preclinical - instrumentation; Equipment Design; Equipment Failure Analysis; Flow Injection Analysis - instrumentation; Humans; Hydrogels - chemistry; Intestinal Absorption - physiology; Materials Testing; Microfluidic Analytical Techniques - instrumentation; Tissue Scaffolds

The absorption of drugs via oral route is a subject of a great interest in drug development process. The current in vitro method for measuring the kinetics of drug absorption relies on 2-D monolayer culture of Caco-2 cells on a porous membrane, but physiologically unrealistic environment provided by...