Oocyte–somatic cell interactions in the human ovary—novel role of bone morphogenetic proteins and growth differentiation factors

• Published in: Human reproduction update Vol. 23; no. 1; pp. 1 - 18
• Main Authors: Chang, Hsun-Ming, Qiao, Jie, Leung, Peter C.K.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2016
• Subjects: Animals; Bone Morphogenetic Proteins - metabolism; Cell Communication - physiology; Female; Growth Differentiation Factors - metabolism; Humans; Mice; Oocytes - physiology; Oogenesis - physiology; Ovarian Follicle - physiology; Ovary - physiology; Ovulation; Review; Transforming Growth Factor beta - metabolism; human granulosa cell line; human ovary; female infertility; growth differentiation factors; human granulosa cells; activin receptor like-kinase; bone morphogenetic proteins

Initially identified for their capability to induce heterotopic bone formation, bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the transforming growth factor β superfamily. Using cellular and molecular genetic approaches, recent studies have implicated intra-ova...