Dynamic Regulation of Middle Cerebral Artery Blood Flow Velocity in Aging and Hypertension

• Published in: Stroke (1970) Vol. 31; no. 8; pp. 1897 - 1903
• Main Authors: Lipsitz, Lewis A., Mukai, Seiji, Hamner, Jason, Gagnon, Margaret, Babikian, Viken
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.08.2000; American Heart Association, Inc
• Subjects: Adult; Aged; Aging - physiology; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Flow Velocity - physiology; Blood Gas Analysis; Blood Pressure - physiology; Cardiology. Vascular system; Cerebrovascular Circulation - physiology; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Female; Homeostasis - physiology; Humans; Hypertension - blood; Hypertension - diagnostic imaging; Hypertension - physiopathology; Hypotension, Orthostatic - blood; Hypotension, Orthostatic - diagnostic imaging; Hypotension, Orthostatic - physiopathology; Male; Medical sciences; Middle Cerebral Artery - diagnostic imaging; Middle Cerebral Artery - physiopathology; Pilot Projects; Posture - physiology; Prognosis; Ultrasonography, Doppler, Transcranial; Sonography; Human; Doppler ultrasound study; Regional blood flow; Nervous system diseases; Senescence; Middle cerebral artery; Cardiovascular disease; Exploration; Transcranial route; Postural hypotension; Spectrum analysis; Diseases of the autonomic nervous system; Adult; Self regulation; Arterial pressure; Hemodynamics; Induced hypercapnia; Elderly; Age; Brain (vertebrata)

Background and Purpose —-Although aging and hypertension may predispose hypertensive elderly subjects to cerebral hypoperfusion during orthostatic stress, their effects on the acute cerebral autoregulatory response to hypotension are not known. Methods —-Continuous middle cerebral artery blood flow...