Synergistic actions of nitrovasodilators and isoprenaline on rat aortic smooth muscle

• Published in: European journal of pharmacology Vol. 192; no. 2; p. 235
• Main Authors: Maurice, D H, Crankshaw, D, Haslam, R J
• Format: Journal Article
• Language: English
• Published: Netherlands 10.01.1991
• Subjects: Adenylyl Cyclases - metabolism; Animals; Aorta - drug effects; Dose-Response Relationship, Drug; Drug Synergism; In Vitro Techniques; Isoproterenol - pharmacology; Male; Molsidomine - analogs & derivatives; Molsidomine - pharmacology; Muscle Contraction - drug effects; Muscle Relaxation - drug effects; Muscle, Smooth, Vascular - drug effects; Nitroprusside - pharmacology; Quinolones - pharmacology; Rats; Rats, Inbred Strains; Vasodilator Agents - pharmacology

Previous studies have established that nitrovasodilators potentiate the inhibition of platelet function by activators of adenylyl cyclase, but uncertainty exists as to whether a comparable effect is seen in vascular smooth muscle. We initially studied the effects of the nitrovasodilators, sodium nit...