Monocytic differentiation induced by side-chain modified analogs of vitamin D in ex vivo cells from patients with acute myeloid leukemia
Abstract The differentiation-inducing potential of side-chain modified analogs of vitamins D, compared to the reference compound, 1,25-dihydroxyvitamin D3 , was studied in blast cells from patients with acute myeloid leukemia and in cell lines. Analogs PRI-1906 and PRI-1907 showed increased cell-dif...
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| Published in | Leukemia research Vol. 38; no. 5; pp. 638 - 647 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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England
Elsevier Ltd
01.05.2014
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| Abstract | Abstract The differentiation-inducing potential of side-chain modified analogs of vitamins D, compared to the reference compound, 1,25-dihydroxyvitamin D3 , was studied in blast cells from patients with acute myeloid leukemia and in cell lines. Analogs PRI-1906 and PRI-1907 showed increased cell-differentiation activities, PRI-1907 even at a very low concentration. Our study revealed a high variability of individual patients’ blasts in their susceptibility to vitamin D analogs. The blasts of the patients with normal karyotype and with mutated NPM1 reacted to analogs with stronger differentiation than the blasts of the remaining patients, while the blasts with mutated FLT3 receptor reacted with weaker differentiation than the remaining blasts. |
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| AbstractList | The differentiation-inducing potential of side-chain modified analogs of vitamins D, compared to the reference compound, 1,25-dihydroxyvitamin D3, was studied in blast cells from patients with acute myeloid leukemia and in cell lines. Analogs PRI-1906 and PRI-1907 showed increased cell-differentiation activities, PRI-1907 even at a very low concentration. Our study revealed a high variability of individual patients' blasts in their susceptibility to vitamin D analogs. The blasts of the patients with normal karyotype and with mutated NPM1 reacted to analogs with stronger differentiation than the blasts of the remaining patients, while the blasts with mutated FLT3 receptor reacted with weaker differentiation than the remaining blasts. The differentiation-inducing potential of side-chain modified analogs of vitamins D, compared to the reference compound, 1,25-dihydroxyvitamin D sub(3), was studied in blast cells from patients with acute myeloid leukemia and in cell lines. Analogs PRI-1906 and PRI-1907 showed increased cell-differentiation activities, PRI-1907 even at a very low concentration. Our study revealed a high variability of individual patients' blasts in their susceptibility to vitamin D analogs. The blasts of the patients with normal karyotype and with mutated NPM1 reacted to analogs with stronger differentiation than the blasts of the remaining patients, while the blasts with mutated FLT3 receptor reacted with weaker differentiation than the remaining blasts. Abstract The differentiation-inducing potential of side-chain modified analogs of vitamins D, compared to the reference compound, 1,25-dihydroxyvitamin D3 , was studied in blast cells from patients with acute myeloid leukemia and in cell lines. Analogs PRI-1906 and PRI-1907 showed increased cell-differentiation activities, PRI-1907 even at a very low concentration. Our study revealed a high variability of individual patients’ blasts in their susceptibility to vitamin D analogs. The blasts of the patients with normal karyotype and with mutated NPM1 reacted to analogs with stronger differentiation than the blasts of the remaining patients, while the blasts with mutated FLT3 receptor reacted with weaker differentiation than the remaining blasts. |
| Author | Baurska, Hanna Marcinkowska, Ewa Kiełbiński, Marek Jaźwiec, Bożena Biecek, Przemysław Haus, Olga Kutner, Andrzej |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24703772$$D View this record in MEDLINE/PubMed |
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| Keywords | Flow cytometry Personalized anticancer therapy Statistical analysis Blasts Vitamin D analogs Differentiation Acute myeloid leukemia 1 ;25-dihydroxyvitamin D 3 1 ;25-dihydroxyvitamin D3 1 ;25-dihydroxyvitamin D |
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| Snippet | Abstract The differentiation-inducing potential of side-chain modified analogs of vitamins D, compared to the reference compound, 1,25-dihydroxyvitamin D3 ,... The differentiation-inducing potential of side-chain modified analogs of vitamins D, compared to the reference compound, 1,25-dihydroxyvitamin D3, was studied... The differentiation-inducing potential of side-chain modified analogs of vitamins D, compared to the reference compound, 1,25-dihydroxyvitamin D sub(3), was... |
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| SubjectTerms | 1 ;25-dihydroxyvitamin D3 Acute myeloid leukemia Adult Aged Aged, 80 and over Blasts Cell Differentiation - drug effects Differentiation Female Flow cytometry fms-Like Tyrosine Kinase 3 - genetics Hematology, Oncology and Palliative Medicine Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Male Middle Aged Monocytes - cytology Mutation Personalized anticancer therapy Statistical analysis Vitamin D - analogs & derivatives Vitamin D analogs |
| Title | Monocytic differentiation induced by side-chain modified analogs of vitamin D in ex vivo cells from patients with acute myeloid leukemia |
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