Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues

• Published in: Aging (Albany, NY.) Vol. 8; no. 6; pp. 1259 - 1275
• Main Authors: Hisamatsu, Daisuke, Ohno-Oishi, Michiko, Nakamura, Shiho, Mabuchi, Yo, Naka-Kaneda, Hayato
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 14.06.2016
• Subjects: Animals; Cell Differentiation - physiology; Cell Proliferation - physiology; Cells, Cultured; Cellular Senescence - physiology; Growth Differentiation Factor 6 - metabolism; Mesenchymal Stromal Cells - metabolism; Mice; MicroRNAs - metabolism; Osteogenesis - physiology; Research Paper; Up-Regulation; miR-17; stem cell aging; aging; Gdf6; SASP; mesenchymal stem cells

The senescence-associated secretory phenotype (SASP) has attracted attention as a mechanism that connects cellular senescence to tissue dysfunction, and specific SASP factors have been identified as systemic pro-aging factors. However, little is known about the age-dependent changes in the secretory...