Leveraging Existing 16S rRNA Gene Surveys To Identify Reproducible Biomarkers in Individuals with Colorectal Tumors

• Published in: mBio Vol. 9; no. 3
• Main Authors: Sze, Marc A., Schloss, Patrick D.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 05.06.2018
• Subjects: 16S rRNA; adenoma; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; biomarkers; Biomarkers - analysis; carcinoma; Colon - microbiology; colorectal cancer; Colorectal Neoplasms - microbiology; diagnostic; DNA, Bacterial - genetics; Feces - microbiology; Gastrointestinal Microbiome; Humans; Phylogeny; RNA, Ribosomal, 16S - genetics; 16S rRNA; adenoma; colorectal cancer; carcinoma; biomarkers; diagnostic; microbiome; feces

An increasing body of literature suggests that both individual and collections of bacteria are associated with the progression of colorectal cancer. As the number of studies investigating these associations increases and the number of subjects in each study increases, a meta-analysis to identify the...