Evaluation of early DNA damage in healthcare workers handling antineoplastic drugs

• Published in: International archives of occupational and environmental health Vol. 80; no. 2; pp. 134 - 140
• Main Authors: Ursini, Cinzia Lucia, Cavallo, Delia, Colombi, Antonio, Giglio, Margherita, Marinaccio, Alessandro, Iavicoli, Sergio
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.11.2006; Springer Nature B.V
• Subjects: Adult; Analysis of Variance; Antineoplastic Agents - analysis; Antineoplastic Agents - toxicity; Antineoplastic drugs; Bioassays; Biological and medical sciences; Biomarkers; Biomonitoring; Cancer Care Facilities; Comet Assay; Cyclophosphamide - analysis; Cyclophosphamide - toxicity; Cytarabine - analysis; Cytarabine - toxicity; Deoxycytidine - analogs & derivatives; Deoxycytidine - analysis; Deoxycytidine - toxicity; Deoxyribonucleic acid; DNA; DNA Damage; Drug toxicity and drugs side effects treatment; Environmental monitoring; Environmental Monitoring - methods; Epidemiological Monitoring; Female; Fluorouracil - analysis; Fluorouracil - toxicity; Health care; Hospitals; Humans; Ifosfamide - analysis; Ifosfamide - toxicity; Italy - epidemiology; Lymphocytes; Lymphocytes - drug effects; Male; Medical personnel; Medical sciences; Metabolites; Middle Aged; Miscellaneous (drug allergy, mutagens, teratogens...); Mouth Mucosa - drug effects; Nurses; Nursing Staff, Hospital - classification; Nursing Staff, Hospital - statistics & numerical data; Occupational exposure; Occupational Exposure - adverse effects; Occupational Exposure - analysis; Pharmacology. Drug treatments; Pharmacy Service, Hospital; Technicians; Italy; Europe; Antineoplastic agent; Human; Drug; Evaluation; Antineoplastic drugs; Health staff; Toxicity; DNA damage; Exfoliated buccal cells; Occupational exposure; Comet assay; Genotoxicity test; Oral cavity; DNA; Early; Occupational medicine; Handling

This study evaluates by comet assay the induction of early DNA damage in healthcare workers of an oncology hospital regularly handling antineoplastic drug mixtures. The aim was to identify a suitable biomarker of DNA damage by exposure to low levels of such drugs. We studied 12 day hospital nurses a...