Incidence and Predictors of Severe Liver Fibrosis in Human Immunodeficiency Virus—Infected Patients with Chronic Hepatitis C: A European Collaborative Study

• Published in: Clinical infectious diseases Vol. 38; no. 1; pp. 128 - 133
• Main Authors: Martín-Carbonero, Luz, Benhamou, Yves, Puoti, Massimo, Berenguer, Juan, Mallolas, José, Quereda, Carmen, Arizcorreta, Ana, Gonzalez, Antonio, Rockstroh, Jurgen, Asensi, Victor, Miralles, Pilar, Laguno, Montse, Moreno, Leonor, Girón, José Antonio, Vogel, Martin, García-Samaniego, Javier, Nuñez, Marina, Romero, Miriam, Moreno, Santiago, de la Cruz, Juan José, Soriano, Vincent
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.01.2004; University of Chicago Press
• Subjects: Adult; Alanine Transaminase - metabolism; antiretroviral therapy; Antiretrovirals; Biological and medical sciences; Biopsies; CD4 antigen; CD4 Lymphocyte Count; Chronic hepatitis; D-Alanine Transaminase; Disease Progression; Female; Fibrosis; Hepacivirus; Hepatitis C virus; Hepatitis C, Chronic - complications; Hepatitis C, Chronic - immunology; Highly active antiretroviral therapy; HIV; HIV Infections - complications; HIV Infections - immunology; HIV/AIDS; Human immunodeficiency virus; Human viral diseases; Humans; Incidence; Infections; Infectious diseases; Liver; Liver Cirrhosis - enzymology; Liver Cirrhosis - epidemiology; Liver Cirrhosis - etiology; Liver Cirrhosis - immunology; Male; Medical sciences; Multivariate Analysis; T lymphocytes; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral hepatitis; Europe; Mixed infection; Hepatic disease; Alcohol; Multivariate analysis; Epidemiology; Incidence; Viral hepatitis A; Immunological investigation; T-Lymphocyte; Antiviral; Serum; Age; Viral hepatitis C; Human; Immunopathology; Enzyme; Critically ill; Transferases; Retroviridae; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Numeration; Chronic; Health center; Biopsy; Transaminases; Viral disease; Fibrosis; Alanine transaminase; Digestive diseases; Human immunodeficiency virus; Flaviviridae; Predictive factor; Severe; Hepatitis C virus; Hepacivirus; Comparative study
• ISSN: 1058-4838; 1537-6591; 1537-6591
• DOI: 10.1086/380130

A study was performed in 10 European health care centers in which 914 patients coinfected with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) who had elevated serum alanine aminotransferase (ALT) levels underwent liver biopsy during the period of 1992 through 2002. Overall, the METAV...