Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging

• Published in: Aging (Albany, NY.) Vol. 13; no. 11; pp. 14651 - 14674
• Main Authors: Baik, Sang-Ha, Selvaraji, Sharmelee, Fann, David Y, Poh, Luting, Jo, Dong-Gyu, Herr, Deron R, Zhang, Shenpeng R, Kim, Hyun Ah, Silva, Michael De, Lai, Mitchell K P, Chen, Christopher Li-Hsian, Drummond, Grant R, Lim, Kah-Leong, Sobey, Christopher G, Arumugam, Thiruma V
• Format: Journal Article
• Language: English
• Published: United States Impact Journals 01.06.2021
• Subjects: Aging - genetics; Animals; Cerebrovascular Circulation - genetics; Chronic Disease; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Hippocampus - blood supply; Hippocampus - metabolism; Male; Mice; Mice, Inbred C57BL; Reproducibility of Results; Research Paper; RNA, Messenger - genetics; RNA, Messenger - metabolism; Time Factors; aging; brain; chronic cerebral hypoperfusion; transcriptome; vascular dementia

Vascular dementia (VaD) is a progressive cognitive impairment of vascular etiology. VaD is characterized by cerebral hypoperfusion, increased blood-brain barrier permeability and white matter lesions. An increased burden of VaD is expected in rapidly aging populations. The hippocampus is particularl...