Hedgehog signaling contributes to basic fibroblast growth factor-regulated fibroblast migration

• Published in: Experimental cell research Vol. 355; no. 2; pp. 83 - 94
• Main Authors: Zhu, Zhong Xin, Sun, Cong Cong, Ting Zhu, Yu, Wang, Ying, Wang, Tao, Chi, Li Sha, Cai, Wan Hui, Zheng, Jia Yong, Zhou, Xuan, Cong, Wei Tao, Li, Xiao Kun, Jin, Li Tai
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.06.2017
• Subjects: 60 APPLIED LIFE SCIENCES; bFGF; Cell Movement; Cells, Cultured; Fibroblast Growth Factor 2 - metabolism; Fibroblast migration; FIBROBLASTS; Fibroblasts - cytology; Fibroblasts - metabolism; GENES; GROWTH FACTORS; HEALING; Hedgehog pathway; Hedgehog Proteins - metabolism; Humans; PHOSPHOTRANSFERASES; POLYMERASE CHAIN REACTION; RNA; Signal Transduction; SKIN; Skin wound healing; THERAPY; TRANSLOCATION; WOUNDS; β-catenin; β-catenin; Skin wound healing; Fibroblast migration; bFGF; Hedgehog pathway

Fibroblast migration is a central process in skin wound healing, which requires the coordination of several types of growth factors. bFGF, a well-known fibroblast growth factor (FGF), is able to accelerate fibroblast migration; however, the underlying mechanism of bFGF regulation fibroblast migratio...