Comparative biological properties of the four stereoisomers of difethialone, a second-generation anticoagulant rodenticide, in rats: development of a model allowing to choose the appropriate stereoisomeric ratio - Lefebvre, Sébastien; Fourel, Isabelle; Chatron, Nolan; Caruel, Hervé; Benoit, Etienne; Lattard, Virginie (Archives of toxicology, 2020)
Keywords: 4-Hydroxycoumarins - pharmacology; Animal biology; Animals; Anticoagulants; Anticoagulants - pharmacology; Baits; Biochemistry; Biochemistry, Molecular Biology; Biological properties; Biomedical and Life Sciences; Biomedicine; Ecotoxicology; Environmental Health; Enzymatic activity; Enzyme activity; Enzymes; Food and Nutrition; Formulations; Green products; Half-life; Laboratory animals; Life Sciences; Male; Modelling; Occupational Medicine/Industrial Medicine; Pests; Pharmacokinetics; Pharmacology; Pharmacology/Toxicology; Predators; Rats; Rodenticides; Rodenticides - pharmacology; Rodents; Stereoisomerism; Stereoisomers; Toxicogenomics; Toxicology; Toxicology and food chain; Veterinary medicine and animal Health; Vitamin K Epoxide Reductases - metabolism; Stereoisomers; VKORC1; Second generation anticoagulant; Chirality; Modelling; Pharmacokinetics; Difethialone