The polymorphism analysis and therapy vaccine target epitopes screening of HPV-35 E6 E7 among the threaten α-9 HPV in Sichuan area

• Published in: Virology journal Vol. 21; no. 1; p. 213
• Main Authors: He, Jiaoyu, Li, Tianjun, Cheng, Chunlan, Li, Ning, Gao, Peng, Lei, Dan, Liang, Rong, Ding, Xianping
• Format: Journal Article
• Language: English
• Published: England BioMed Central 09.09.2024; BMC
• Subjects: Adult; Alphapapillomavirus - classification; Alphapapillomavirus - genetics; Alphapapillomavirus - immunology; amino acid substitution; China; chronic diseases; E6 polymorphisms; E7 polymorphisms; epitopes; Epitopes - genetics; Epitopes - immunology; Female; Genotype; genotyping; genus; HPV35; Human Papillomavirus; Human Papillomavirus Viruses; Humans; immune system; Middle Aged; Mutation; oncogene proteins; Oncogene Proteins, Viral - genetics; Oncogene Proteins, Viral - immunology; Papillomaviridae; Papillomavirus E7 Proteins - genetics; Papillomavirus E7 Proteins - immunology; Papillomavirus Infections - prevention & control; Papillomavirus Infections - virology; Papillomavirus Vaccines - genetics; Papillomavirus Vaccines - immunology; peptides; Polymorphism, Genetic; Protein structure; therapeutics; uterine cervical neoplasms; Uterine Cervical Neoplasms - prevention & control; Uterine Cervical Neoplasms - virology; vaccine development; vaccines; viruses; α-9 genus HPV; China; E7 polymorphisms; Antigen epitope; Positive selection site; Human Papillomavirus; HPV35; Protein structure; E6 polymorphisms; α-9 genus HPV

High-risk human papilloma virus (HR-HPV) persistent infection is closely associated with the development of cervical cancer and squamous intraepithelial lesion (SIL).The α-9 HPVs, which is predominantly composed of HR-HPV types, account for 75% of HR-HPV infection in Sichuan. The oncoproteins E6 and...