Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma

• Published in: Frontiers in neuroscience Vol. 8; p. 290
• Main Authors: Dengler-Crish, Christine M, Smith, Matthew A, Inman, Denise M, Wilson, Gina N, Young, Jesse W, Crish, Samuel D
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 17.09.2014; Frontiers Media S.A
• Subjects: Age; Alzheimer's disease; Anterograde transport; Axon guidance; Axonal Transport; Cholera toxin; Gene expression; Glaucoma; Menopause; Neurodegeneration; Neurodegenerative diseases; Neurons; Neurosciences; Optic Nerve; Pathology; Phosphorylation; Psychiatry; Retina; Retrograde transport; Superior Colliculi; Superior colliculus; Traffic congestion; Vision Disorders; Vision, Ocular; United States > US; axonopathy; glaucoma; axonal transport; neurodegeneration; superior colliculi; optic nerve; vision disorders; ocular

Axonal transport deficits have been reported as an early pathology in several neurodegenerative disorders, including glaucoma. However, the progression and mechanisms of these deficits are poorly understood. Previous work suggests that anterograde transport is affected earlier and to a larger degree...