A Matrix Protein Silences Transposons and Repeats through Interaction with Retinoblastoma-Associated Proteins

• Published in: Current biology Vol. 23; no. 4; pp. 345 - 350
• Main Authors: Xu, Yifeng, Wang, Yizhong, Stroud, Hume, Gu, Xiaofeng, Sun, Bo, Gan, Eng-Seng, Ng, Kian-Hong, Jacobsen, Steven E., He, Yuehui, Ito, Toshiro
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 18.02.2013
• Subjects: acetylation; Arabidopsis; Arabidopsis - genetics; Chromatin; Chromatin - genetics; Chromatin - metabolism; Deacetylation; Derepression; DNA Methylation; DNA Transposable Elements - genetics; DNA-binding domains; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Epigenesis, Genetic; epigenetics; Flowering; Gene expression; Gene Expression Regulation, Plant; genes; Genomes; genomics; Histones; loci; Lysine; matrix protein; Methylation; Mutation; nuclear matrix; Nuclear Matrix-Associated Proteins - genetics; Regulatory sequences; Repeated DNA sequences; Repressors; Retinoblastoma Binding Proteins - metabolism; retinoblastoma-associated protein; RNA Interference; RNA, Small Interfering; Transposition; Transposons

Epigenetic regulation helps to maintain genomic integrity by suppressing transposable elements (TEs) and also controls key developmental processes, such as flowering time [1–3]. To prevent TEs from causing rearrangements and mutations, TE and TE-like repetitive DNA sequences are usually methylated,...