Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

• Published in: Brain (London, England : 1878) Vol. 143; no. 10; pp. 3041 - 3051
• Main Authors: Borsche, Max, König, Inke R, Delcambre, Sylvie, Petrucci, Simona, Balck, Alexander, Brüggemann, Norbert, Zimprich, Alexander, Wasner, Kobi, Pereira, Sandro L, Avenali, Micol, Deuschle, Christian, Badanjak, Katja, Ghelfi, Jenny, Gasser, Thomas, Kasten, Meike, Rosenstiel, Philip, Lohmann, Katja, Brockmann, Kathrin, Valente, Enza Maria, Youle, Richard J, Grünewald, Anne, Klein, Christine
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.10.2020
• Subjects: Adult; Aged; Biomarkers - blood; Cross-Sectional Studies; DNA, Mitochondrial - blood; Female; Humans; Inflammation - blood; Inflammation - genetics; Interleukin-6 - blood; Male; Middle Aged; Original; Parkinsonian Disorders - blood; Parkinsonian Disorders - genetics; Protein Kinases - genetics; Retrospective Studies; Ubiquitin-Protein Ligases - genetics; IL6; PINK1; parkin; Parkinson’s disease; ccf-mtDNA

There is increasing evidence for a role of inflammation in Parkinson’s disease. Recent research in murine models suggests that parkin and PINK1 deficiency leads to impaired mitophagy, which causes the release of mitochondrial DNA (mtDNA), thereby triggering inflammation. Specifically, the CGAS (cycl...