Control of response reliability by parvalbumin-expressing interneurons in visual cortex

• Published in: Nature communications Vol. 6; no. 1; p. 6802
• Main Authors: Zhu, Yingjie, Qiao, Wenhui, Liu, Kefei, Zhong, Huiyuan, Yao, Haishan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.04.2015; Nature Publishing Group
• Subjects: 631/378/2571/1696; 631/378/2613; 64/60; Anesthesia; Animals; Evoked Potentials, Visual - genetics; Gene Expression; Genes, Reporter; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Humanities and Social Sciences; Interneurons - cytology; Interneurons - metabolism; Mice; Mice, Transgenic; multidisciplinary; Neural Inhibition - genetics; Optogenetics; Parvalbumins - genetics; Parvalbumins - metabolism; Photic Stimulation; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - metabolism; Reproducibility of Results; Rhodopsins, Microbial - genetics; Rhodopsins, Microbial - metabolism; Science; Science (multidisciplinary); Signal-To-Noise Ratio; Somatostatin - genetics; Somatostatin - metabolism; Synaptic Transmission - genetics; Visual Cortex - cytology; Visual Cortex - metabolism; Wakefulness - physiology

The responses of visual cortical neurons to natural stimuli are both reliable and sparse. These properties require inhibition, yet the contribution of specific types of inhibitory neurons is not well understood. Here we demonstrate that optogenetic suppression of parvalbumin (PV)- but not somatostat...