The Action of Antidepressants on the Glutamate System: Regulation of Glutamate Release and Glutamate Receptors

• Published in: Biological psychiatry (1969) Vol. 73; no. 12; pp. 1180 - 1188
• Main Authors: Musazzi, Laura, Treccani, Giulia, Mallei, Alessandra, Popoli, Maurizio
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.06.2013; Elsevier
• Subjects: Animals; Antidepressant; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Brain - physiopathology; Drug Design; drug development; glutamate neurotransmission; glutamate receptor; glutamate release; Glutamic Acid - metabolism; Humans; ketamine; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Receptors, Glutamate - metabolism; Antidepressant; drug development; ketamine; glutamate neurotransmission; glutamate receptor; glutamate release; Psychotropic; Glutamate receptor; Glutamate; Ketamine; General anesthetic; Excitatory aminoacid; Neurotransmitter; Development; Antidepressant agent; Drug of abuse; Antagonist; NMDA receptor; Release; Neurotransmission

Recent compelling evidence has suggested that the glutamate system is a primary mediator of psychiatric pathology and also a target for rapid-acting antidepressants. Clinical research in mood and anxiety disorders has shown alterations in levels, clearance, and metabolism of glutamate and consistent...