Population Structure, Molecular Epidemiology, and β-Lactamase Diversity among Stenotrophomonas maltophilia Isolates in the United States

• Published in: mBio Vol. 10; no. 4
• Main Authors: Mojica, Maria F., Rutter, Joseph D., Taracila, Magdalena, Abriata, Luciano A., Fouts, Derrick E., Papp-Wallace, Krisztina M., Walsh, Thomas J., LiPuma, John J., Vila, Alejandro J., Bonomo, Robert A.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 02.07.2019
• Subjects: Anti-Bacterial Agents - pharmacology; antibiotic resistance; Azabicyclo Compounds - pharmacology; Aztreonam - pharmacology; beta-Lactamase Inhibitors - pharmacology; beta-lactamases; beta-Lactamases - genetics; Ceftazidime - pharmacology; Clinical Science and Epidemiology; Drug Combinations; Drug Resistance, Multiple, Bacterial; Genetic Variation; Genotype; Gram-Negative Bacterial Infections - epidemiology; Gram-Negative Bacterial Infections - microbiology; Humans; Microbial Sensitivity Tests; Microbiological Techniques; Molecular Epidemiology; Multilocus Sequence Typing; Stenotrophomonas maltophilia; Stenotrophomonas maltophilia - classification; Stenotrophomonas maltophilia - enzymology; Stenotrophomonas maltophilia - genetics; Stenotrophomonas maltophilia - isolation & purification; United States; United States; Stenotrophomonas maltophilia; molecular epidemiology; beta-lactamases; antibiotic resistance

Multiple antibiotic resistance mechanisms, including two β-lactamases, L1, a metallo-β-lactamase, and L2, a class A cephalosporinase, make S. maltophilia naturally multidrug resistant. Thus, infections caused by S. maltophilia pose a big therapeutic challenge. Our study aims to understand the microb...