Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS): A New Tool for the Analysis of Toxicological Effects on Single Cell Level

• Published in: Toxics (Basel) Vol. 4; no. 1; p. 5
• Main Authors: Jungnickel, Harald, Laux, Peter, Luch, Andreas
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 15.02.2016; MDPI AG
• Subjects: cryopreservation; imaging mass spectrometry; lipidomics; MIMS; Review; single cell analysis; ToF-SIMS; imaging mass spectrometry; ToF-SIMS; single cell analysis; MIMS; cryopreservation; lipidomics

Single cell imaging mass spectrometry opens up a complete new perspective for strategies in toxicological risk assessment and drug discovery. In particular, time-of-flight secondary ion mass spectrometry (ToF-SIMS) with its high spatial and depth resolution is becoming part of the imaging mass spect...