Limited ER quality control for GPI-anchored proteins

• Published in: The Journal of cell biology Vol. 213; no. 6; pp. 693 - 704
• Main Authors: Sikorska, Natalia, Lemus, Leticia, Aguilera-Romero, Auxiliadora, Manzano-Lopez, Javier, Riezman, Howard, Muñiz, Manuel, Goder, Veit
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 20.06.2016
• Subjects: Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum - physiology; Endoplasmic Reticulum-Associated Degradation - physiology; Fungal Proteins - metabolism; Glycosylphosphatidylinositols - metabolism; Protein Binding - physiology; Protein Folding; Yeasts - metabolism; Yeasts - physiology

Endoplasmic reticulum (ER) quality control mechanisms target terminally misfolded proteins for ER-associated degradation (ERAD). Misfolded glycophosphatidylinositol-anchored proteins (GPI-APs) are, however, generally poor ERAD substrates and are targeted mainly to the vacuole/lysosome for degradatio...