Interaction of Mycobacterium tuberculosis Virulence Factor RipA with Chaperone MoxR1 Is Required for Transport through the TAT Secretion System

• Published in: mBio Vol. 7; no. 2; p. e02259
• Main Authors: Bhuwan, Manish, Arora, Naresh, Sharma, Ashish, Khubaib, Mohd, Pandey, Saurabh, Chaudhuri, Tapan Kumar, Hasnain, Seyed Ehtesham, Ehtesham, Nasreen Zafar
• Format: Journal Article
• Language: English
• Published: United States American Society of Microbiology 01.03.2016; American Society for Microbiology
• Subjects: Bacterial Proteins - genetics; Bacterial Proteins - isolation & purification; Bacterial Proteins - metabolism; Cell Line; Epithelial Cells - microbiology; Escherichia coli - genetics; Escherichia coli - metabolism; Humans; Mycobacterium smegmatis - genetics; Mycobacterium smegmatis - metabolism; Mycobacterium tuberculosis - enzymology; Mycobacterium tuberculosis - metabolism; Protein Interaction Mapping; Twin-Arginine-Translocation System - metabolism; Virulence Factors - metabolism

Mycobacterium tuberculosis is a leading cause of death worldwide. The M. tuberculosis TAT (twin-arginine translocation) protein secretion system is present at the cytoplasmic membrane of mycobacteria and is known to transport folded proteins. The TAT secretion system is reported to be essential for...