Complete Microbiota Engraftment Is Not Essential for Recovery from Recurrent Clostridium difficile Infection following Fecal Microbiota Transplantation

• Published in: mBio Vol. 7; no. 6
• Main Authors: Staley, Christopher, Kelly, Colleen R., Brandt, Lawrence J., Khoruts, Alexander, Sadowsky, Michael J.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 20.12.2016
• Subjects: Adult; Aged; Bacteroidetes - isolation & purification; Bayes Theorem; Clinical Trials as Topic; Clostridium difficile - isolation & purification; Clostridium Infections - microbiology; Clostridium Infections - therapy; Diarrhea - microbiology; Fecal Microbiota Transplantation - methods; Fecal Microbiota Transplantation - standards; Feces - microbiology; Female; Firmicutes - isolation & purification; Gastrointestinal Microbiome; Healthy Volunteers; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Recurrence; Remission Induction - methods

Bacterial communities from subjects treated for recurrent Clostridium difficile infection (rCDI) by fecal microbiota transplantation (FMT), using either heterologous donor stool samples or autologous stool samples, were characterized by Illumina next-generation sequencing. As previously reported, th...