Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis

• Published in: mBio Vol. 10; no. 3
• Main Authors: Fritzlar, Svenja, Aktepe, Turgut E, Chao, Yi-Wei, Kenney, Nathan D, McAllaster, Michael R, Wilen, Craig B, White, Peter A, Mackenzie, Jason M
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 18.06.2019
• Subjects: Animals; Caliciviridae Infections - immunology; Cytoplasmic Granules - immunology; Cytoplasmic Granules - virology; DNA Helicases - immunology; Editor's Pick; eIF-2 Kinase - immunology; eIF2α; Eukaryotic Initiation Factor-2 - immunology; Host-Microbe Biology; Host-Pathogen Interactions; Immune Evasion; Immunity, Innate; integrated stress response; Mice; mouse norovirus; Phosphorylation; Poly-ADP-Ribose Binding Proteins - immunology; Protein Biosynthesis; protein kinase R; protein translation; RNA Helicases - immunology; RNA Recognition Motif Proteins - immunology; stress granules; Viral Proteins - genetics; Viral Proteins - metabolism; Virus Replication; eIF2α; stress granules; protein translation; mouse norovirus; integrated stress response; protein kinase R

The integrated stress response (ISR) is a cellular response system activated upon different types of stresses, including viral infection, to restore cellular homeostasis. However, many viruses manipulate this response for their own advantage. In this study, we investigated the association between mu...