Probiotics as a possible novel therapeutic option to mitigate perioperative neurocognitive disorders: A review exploring the latest research findings

• Published in: Journal of clinical anesthesia Vol. 103; p. 111801
• Main Authors: Horill, Smita, Zhou, Xiao-Kai, Jin, Wenjie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2025; Elsevier Limited
• Subjects: Anesthesia; Anesthesia - adverse effects; Antibiotics; Brain research; Chemokines; Cytokines; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - physiology; Gastrointestinal surgery; Gut dysbiosis; Gut microbiome; Gut-brain axis; Humans; Immunomodulators; Inflammation; Memory; Metabolites; Microbiota; Microbiota-gut-brain axis; Microorganisms; Nervous system; Neurocognitive Disorders - etiology; Neurocognitive Disorders - prevention & control; Neurocognitive Disorders - therapy; Neuroinflammation; Older people; Pain Medicine; Perioperative care; Perioperative Care - methods; Perioperative neurocognitive disorders; Permeability; Postoperative Cognitive Complications - prevention & control; Probiotics; Probiotics - administration & dosage; Probiotics - therapeutic use; CRP; PCT; Microbiota-gut-brain axis; KYNA; BBB; POCD; PND; CNS; PSCI; TNF; LPS; PSD 95; CFU; MMSE; NMDA; TLR; AD; IL; BDNF; Neuroinflammation; EN; MGB; NGF; SCFA; Perioperative neurocognitive disorders; QUIN; Probiotics; CPB; PD; SAE; GABA; HPA; NF; Gut dysbiosis; ISAPP; Gut microbiome; DAMP; C-reactive protein; Parkinson's disease; N-methyl- d-aspartate; quinolinic acid; microbiota-gut-brain; sepsis-associated encephalopathy; damage-associated molecular pattern; cardiopulmonary bypass; brain-derived neurotrophic factor; Alzheimer's disease; Toll-like receptor; enteral nutrition; gamma-aminobutyric acid; central nervous system; nuclear factor; kynurenic acid; Mini-Mental State Examination; short-chain fatty acid; blood-brain-barrier; postoperative cognitive dysfunction; postsynaptic density protein 95; post-stroke cognitive impairment; International Scientific Association for Probiotics and Prebiotics; procalcitonin; nerve growth factor; interleukin; hypothalamic-pituitary-adrenal; lipopolysaccharides; tumor necrosis factor; colony forming unit

Perioperative neurocognitive disorders (PND) refer to a constellation of symptoms that primarily affect the elderly and typically manifest as common complications after exposure to surgery and anesthesia. PND is associated with high morbidity, mortality, and progression to neurodegenerative diseases...