Dip1 Defines a Class of Arp2/3 Complex Activators that Function without Preformed Actin Filaments

• Published in: Current biology Vol. 23; no. 20; pp. 1990 - 1998
• Main Authors: Wagner, Andrew R., Luan, Qing, Liu, Su-Ling, Nolen, Brad J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 21.10.2013
• Subjects: actin; Actin Cytoskeleton - metabolism; Actin-Related Protein 2-3 Complex - genetics; Actin-Related Protein 2-3 Complex - metabolism; Amino Acid Sequence; binding proteins; Electrophoresis, Polyacrylamide Gel; Immunoblotting; microfilaments; Microscopy, Fluorescence; Molecular Sequence Data; regulator genes; Schizosaccharomyces - genetics; Schizosaccharomyces - metabolism; Schizosaccharomyces pombe Proteins - genetics; Schizosaccharomyces pombe Proteins - metabolism; Sequence Alignment; transcription factors

Arp2/3 complex is a key actin cytoskeletal regulator that creates branched actin filament networks in response to cellular signals. WASP-activated Arp2/3 complex assembles branched actin networks by nucleating new filaments from the sides of pre-existing ones. WASP-mediated activation requires seed...