The value of S-phase and DNA ploidy analysis as prognostic markers for node-negative breast cancer in the australian setting
This study aimed to determine the prognostic significance of DNA ploidy and S-phase fraction (SPF) measurements in our laboratory for patients with node-negative breast cancer. Frozen tumors from axillary node-negative breast cancer patients (n=50) treated at Westmead Hospital, NSW, between 1988 and...
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Published in | Pathology Vol. 31; no. 2; pp. 90 - 94 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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London
Elsevier B.V
01.05.1999
Informa UK Ltd Taylor and Francis |
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Abstract | This study aimed to determine the prognostic significance of DNA ploidy and S-phase fraction (SPF) measurements in our laboratory for patients with node-negative breast cancer. Frozen tumors from axillary node-negative breast cancer patients (n=50) treated at Westmead Hospital, NSW, between 1988 and 1991 were analysed by flow cytometry. The median duration of follow-up for all patients was 8.4 years. Forty-six specimens provided evaluable DNA histograms with 43% (n=20) diploid and 56% (n=26) aneuploid tumors identified. Comparisons of DNA ploidy status and SPF were made with traditional prognostic variables, which included age, menopausal status, tumor size, histologic grade and hormone receptor status. Our results showed that there was no significant difference in disease-free or overall survival between patients with diploid and aneuploid tumors. Histologic grade 3 tumors were more likely to be aneuploid and had higher SPF than grade 1 or 2 tumors. Patients with grade 3 tumors and a high SPF were four times more likely to relapse than the rest of the population. These results indicate that DNA flow cytometric analysis in our laboratory provides additional prognostic data that could be utilised alongside traditional clinical and histopathologic indicators for predicting outcome for patients. |
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AbstractList | This study aimed to determine the prognostic significance of DNA ploidy and S-phase fraction (SPF) measurements in our laboratory for patients with node-negative breast cancer. Frozen tumors from axillary node-negative breast cancer patients (n=50) treated at Westmead Hospital, NSW, between 1988 and 1991 were analysed by flow cytometry. The median duration of follow-up for all patients was 8.4 years. Forty-six specimens provided evaluable DNA histograms with 43% (n=20) diploid and 56% (n=26) aneuploid tumors identified. Comparisons of DNA ploidy status and SPF were made with traditional prognostic variables, which included age, menopausal status, tumor size, histologic grade and hormone receptor status. Our results showed that there was no significant difference in disease-free or overall survival between patients with diploid and aneuploid tumors. Histologic grade 3 tumors were more likely to be aneuploid and had higher SPF than grade 1 or 2 tumors. Patients with grade 3 tumors and a high SPF were four times more likely to relapse than the rest of the population. These results indicate that DNA flow cytometric analysis in our laboratory provides additional prognostic data that could be utilised alongside traditional clinical and histopathologic indicators for predicting outcome for patients. |
Author | Wong, Sue W.J. Rangan, Anna M. Benson, Elizabeth M. Gebski, Val Michael Bilous, A. Boyages, John |
Author_xml | – sequence: 1 givenname: Sue W.J. surname: Wong fullname: Wong, Sue W.J. organization: Departments of Immunopathology, New South Wales, Australia – sequence: 2 givenname: Anna M. surname: Rangan fullname: Rangan, Anna M. organization: Institute of Clinical Pathology and Medical Research, The New South Wales Breast Cancer Institute, New South Wales, Australia – sequence: 3 givenname: A. surname: Michael Bilous fullname: Michael Bilous, A. organization: Anatomical Pathology, New South Wales, Australia – sequence: 4 givenname: John surname: Boyages fullname: Boyages, John organization: Institute of Clinical Pathology and Medical Research, The New South Wales Breast Cancer Institute, New South Wales, Australia – sequence: 5 givenname: Val surname: Gebski fullname: Gebski, Val organization: Department of Radiation Oncology, New South Wales, Australia – sequence: 6 givenname: Elizabeth M. surname: Benson fullname: Benson, Elizabeth M. organization: Departments of Immunopathology, New South Wales, Australia |
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CitedBy_id | crossref_primary_10_1078_0344_0338_00123 crossref_primary_10_1007_BF03032578 crossref_primary_10_1038_sj_onc_1204148 crossref_primary_10_1186_1746_1596_1_41 crossref_primary_10_1038_modpathol_3880120 crossref_primary_10_1038_srep05122 crossref_primary_10_3892_ol_2014_2367 |
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Copyright | 1999 Royal College of Pathologists of Australasia 1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999 1999 INIST-CNRS |
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Keywords | DNA ploidy DFS S-phase fraction PR PCNA node-negative breast cancer DI SPF DNA flow cytometry PBL ER Human Immunohistochemistry Flow cytometry Ploidy Carcinoma Prognosis Malignant tumor Pathology Mammary gland diseases DNA S Phase Predictive value Female Mammary gland |
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SubjectTerms | Adult Aged Aneuploidy Australia Biological and medical sciences Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Carcinoma, Ductal, Breast - diagnosis Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - pathology Cohort Studies DNA flow cytometry DNA ploidy Female Flow Cytometry Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Middle Aged node-negative breast cancer Ploidies Predictive Value of Tests Prognosis Retrospective Studies S Phase - genetics S-phase fraction Survival Rate Tropical medicine Tumors |
Title | The value of S-phase and DNA ploidy analysis as prognostic markers for node-negative breast cancer in the australian setting |
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