Progress in Elucidating Potential Markers and Mechanisms of Rapid Protection Conferred by the VSV-Vectored Ebola Virus Vaccine

• Published in: mBio Vol. 10; no. 4
• Main Author: Wong, Gary
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 16.07.2019
• Subjects: Animals; Ebola; Ebola Vaccines - genetics; Ebola Vaccines - immunology; Ebolavirus - genetics; Ebolavirus - immunology; Genetic Vectors - administration & dosage; Genetic Vectors - genetics; Hemorrhagic Fever, Ebola - prevention & control; Primates; Therapeutics and Prevention; vaccine; vesicular stomatitis virus; Vesiculovirus - genetics; Ebola; vaccine; vesicular stomatitis virus

Research progress over the past 20 years has yielded several experimental Ebola virus (EBOV) vaccine candidates, which were shown to be effective in nonhuman primates when given 28 days before a lethal challenge. Of these, the vesicular stomatitis virus (VSV)-vectored vaccine against EBOV (VSV-EBOV)...