Emergence, molecular mechanisms and global spread of carbapenem-resistant Acinetobacter baumannii

• Published in: Microbial genomics Vol. 5; no. 10
• Main Authors: Hamidian, Mohammad, Nigro, Steven J.
• Format: Journal Article
• Language: English
• Published: England Microbiology Society 01.10.2019
• Subjects: Acinetobacter baumannii - genetics; Acinetobacter Infections - epidemiology; Acinetobacter Infections - microbiology; Anti-Bacterial Agents - metabolism; beta-Lactam Resistance - genetics; Carbapenems - metabolism; Databases, Genetic; DNA Transposable Elements - genetics; DNA, Bacterial - genetics; Genome, Bacterial - genetics; Humans; Mini Review; Tn2006; global clones; oxa23; oxa235; oxa24; oxa58; AbaR4 and plasmid; Acinetobacter baumannii; GC1; carbapenem resistance; GC2; Tn2008; Tn2009

Acinetobacter baumannii is a nosocomial pathogen that has emerged as a global threat because of high levels of resistance to many antibiotics, particularly those considered to be last-resort antibiotics, such as carbapenems. Although alterations in the efflux pump and outer membrane proteins can cau...