Tagging sentinel lymph nodes: a study of 100 patients with breast cancer

• Published in: European journal of cancer (1990) Vol. 35; no. 4; pp. 569 - 573
• Main Authors: Bobin, J.-Y., Zinzindohoue, C., Isaac, S., Saadat, M., Roy, P.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.04.1999; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Axilla; axillary lymph node dissection; Biological and medical sciences; breast cancer; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Evans Blue; Female; Gynecology. Andrology. Obstetrics; Humans; internal mammary chain; Life Sciences; Lymph Node Excision; Lymph Nodes - pathology; Lymphatic Metastasis; Mammary gland diseases; Mastectomy - methods; Medical sciences; Middle Aged; Neoplasm Staging - methods; Sensitivity and Specificity; sentinel lymph nodes; staging; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the genital tract and mammary gland; Tumors; breast cancer; sentinel lymph nodes; internal mammary chain; staging; axillary lymph node dissection; Human; Immunohistochemistry; Evaluation; Lymph node; Stage classification; Metastasis; Malignant tumor; Optimization; Mammary gland diseases; Surgery; Female; Diagnosis; Mammary gland; Technique
• ISSN: 0959-8049; 1879-0852
• DOI: 10.1016/S0959-8049(99)00009-X

The aim of this study was to evaluate in breast cancer patients the feasibility of sentinel lymph node (SLN) identification and the sensitivity of this technique to detect node metastases. Between January and July 1997, SLNs were tracked with Evans Blue dye in 100 patients with breast cancer who then underwent complete level I/II axillary lymph node dissection (ALND). All SLNs were examined by haematoxylin–phloxin–saffron (HPS) staining and immunohistochemistry (IHC) of multiple sections. The findings for the SLNs were compared with results on ANLD. Axillary SLNs were identified in 83 patients (detection rate=83%; 95% confidence interval (CI) 74–90%). Axillary SLNs were detected in 58/83 cases (70%) at level I only, and in 69/83 (83%) at levels including level I. Histologically positive axillary SLNs were found in 45% (37/83) of patients, including 2 patients with malignancy (micrometastases) detected by IHC only. The sensitivity of axillary SLN to detect axillary lymph nodes metastases was 37/39=95% (95% CI 83–99%). SLNs of the internal mammary chain (IMC) were dissected for 33 tumours of the median or inner quadrants and detected in 26/33=79% of cases (95% CI 61–91%). In our experience, the overall sensitivity of SLN identification as a predictor of node (axillary or IMC) metastases was 41/43=95% (95% CI 84–99%), confirming the usefulness of the procedure.