Minocycline blocks glial cell activation and ventilatory acclimatization to hypoxia

• Published in: Journal of neurophysiology Vol. 117; no. 4; pp. 1625 - 1635
• Main Authors: Stokes, Jennifer A., Arbogast, Tara E., Moya, Esteban A., Fu, Zhenxing, Powell, Frank L.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.04.2017
• Series: Glial Cells and Neuronal Signaling
• Subjects: Acclimatization - drug effects; Analysis of Variance; Animals; Anti-Bacterial Agents - pharmacology; Glial Fibrillary Acidic Protein - metabolism; Hypoxia - pathology; Male; Minocycline - pharmacology; Neuroglia - drug effects; Plethysmography; Rats; Rats, Sprague-Dawley; Respiration - drug effects; Respiratory Center - pathology; Solitary Nucleus - cytology; nucleus tractus solitarius; astrocytes; rat; neural plasticity; microglia; hypoxic ventilatory response

Ventilatory acclimatization to hypoxia (VAH) is the time-dependent increase in ventilation, which persists upon return to normoxia and involves plasticity in both central nervous system respiratory centers and peripheral chemoreceptors. We investigated the role of glial cells in VAH in male Sprague-...