Kinetic modelling of starch and lipid formation during mixotrophic, nutrient-limited microalgal growth

•We developed a new kinetic model to predict microalgal starch and lipid formation.•Model dynamics were experimentally validated for a range of conditions.•The model can account for coupled acetate and nitrogen concentration changes.•Optimal initial feed strategies are computed to maximise starch &a...

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Published inBioresource technology Vol. 241; pp. 868 - 878
Main Authors Figueroa-Torres, Gonzalo M., Pittman, Jon K., Theodoropoulos, Constantinos
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2017
Subjects
Biofuels
Biomass
Chlamydomonas reinhardtii
Kinetic modelling
Lipids
Microalgae
Microalgal dynamics
Starch
Starch and lipids optimisation
Starch and lipids optimisation
Biofuels
Kinetic modelling
Chlamydomonas reinhardtii
Microalgal dynamics
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Abstract •We developed a new kinetic model to predict microalgal starch and lipid formation.•Model dynamics were experimentally validated for a range of conditions.•The model can account for coupled acetate and nitrogen concentration changes.•Optimal initial feed strategies are computed to maximise starch & lipid production.•Experimental validation of optimal results showed excellent agreement. Microalgal starch and lipids, carbon-based storage molecules, are useful as potential biofuel feedstocks. In this work, cultivation strategies maximising starch and lipid formation were established by developing a multi-parameter kinetic model describing microalgal growth as well as starch and lipid formation, in conjunction with laboratory-scale experiments. Growth dynamics are driven by nitrogen-limited mixotrophic conditions, known to increase cellular starch and lipid contents whilst enhancing biomass growth. Model parameters were computed by fitting model outputs to a range of experimental datasets from batch cultures of Chlamydomonas reinhardtii. Predictive capabilities of the model were established against different experimental data. The model was subsequently used to compute optimal nutrient-based cultivation strategies in terms of initial nitrogen and carbon concentrations. Model-based optimal strategies yielded a significant increase of 261% for starch (0.065gCL−1) and 66% for lipid (0.08gCL−1) production compared to base-case conditions (0.018gCL−1 starch, 0.048gCL−1 lipids).
AbstractList Microalgal starch and lipids, carbon-based storage molecules, are useful as potential biofuel feedstocks. In this work, cultivation strategies maximising starch and lipid formation were established by developing a multi-parameter kinetic model describing microalgal growth as well as starch and lipid formation, in conjunction with laboratory-scale experiments. Growth dynamics are driven by nitrogen-limited mixotrophic conditions, known to increase cellular starch and lipid contents whilst enhancing biomass growth. Model parameters were computed by fitting model outputs to a range of experimental datasets from batch cultures of Chlamydomonas reinhardtii. Predictive capabilities of the model were established against different experimental data. The model was subsequently used to compute optimal nutrient-based cultivation strategies in terms of initial nitrogen and carbon concentrations. Model-based optimal strategies yielded a significant increase of 261% for starch (0.065gCL-1) and 66% for lipid (0.08gCL-1) production compared to base-case conditions (0.018gCL-1 starch, 0.048gCL-1 lipids).
Microalgal starch and lipids, carbon-based storage molecules, are useful as potential biofuel feedstocks. In this work, cultivation strategies maximising starch and lipid formation were established by developing a multi-parameter kinetic model describing microalgal growth as well as starch and lipid formation, in conjunction with laboratory-scale experiments. Growth dynamics are driven by nitrogen-limited mixotrophic conditions, known to increase cellular starch and lipid contents whilst enhancing biomass growth. Model parameters were computed by fitting model outputs to a range of experimental datasets from batch cultures of Chlamydomonas reinhardtii. Predictive capabilities of the model were established against different experimental data. The model was subsequently used to compute optimal nutrient-based cultivation strategies in terms of initial nitrogen and carbon concentrations. Model-based optimal strategies yielded a significant increase of 261% for starch (0.065gCL ) and 66% for lipid (0.08gCL ) production compared to base-case conditions (0.018gCL starch, 0.048gCL lipids).
•We developed a new kinetic model to predict microalgal starch and lipid formation.•Model dynamics were experimentally validated for a range of conditions.•The model can account for coupled acetate and nitrogen concentration changes.•Optimal initial feed strategies are computed to maximise starch & lipid production.•Experimental validation of optimal results showed excellent agreement. Microalgal starch and lipids, carbon-based storage molecules, are useful as potential biofuel feedstocks. In this work, cultivation strategies maximising starch and lipid formation were established by developing a multi-parameter kinetic model describing microalgal growth as well as starch and lipid formation, in conjunction with laboratory-scale experiments. Growth dynamics are driven by nitrogen-limited mixotrophic conditions, known to increase cellular starch and lipid contents whilst enhancing biomass growth. Model parameters were computed by fitting model outputs to a range of experimental datasets from batch cultures of Chlamydomonas reinhardtii. Predictive capabilities of the model were established against different experimental data. The model was subsequently used to compute optimal nutrient-based cultivation strategies in terms of initial nitrogen and carbon concentrations. Model-based optimal strategies yielded a significant increase of 261% for starch (0.065gCL−1) and 66% for lipid (0.08gCL−1) production compared to base-case conditions (0.018gCL−1 starch, 0.048gCL−1 lipids).
Author Figueroa-Torres, Gonzalo M.
Pittman, Jon K.
Theodoropoulos, Constantinos
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Cites_doi 10.1016/S0032-9592(99)00082-5
10.1007/BF00003874
10.1016/j.enzmictec.2012.07.013
10.1515/botm.1983.26.3.99
10.1073/pnas.1118012108
10.1016/j.jprocont.2011.07.012
10.1016/j.biortech.2010.02.016
10.1016/j.biortech.2014.01.032
10.1016/j.rser.2008.08.014
10.1007/s00253-012-4398-0
10.1002/bit.260100602
10.1093/pcp/pcs082
10.1080/01904160802208345
10.1002/bit.22033
10.1002/bit.22034
10.1016/j.algal.2016.12.015
10.1002/bit.24474
10.1016/j.algal.2013.09.003
10.1128/EC.05242-11
10.1128/EC.00013-14
10.1016/j.algal.2015.10.004
10.1016/j.rser.2009.10.009
10.1007/s11306-015-0878-4
10.1016/j.apenergy.2011.03.012
10.1016/j.rser.2014.12.024
10.1002/bit.23016
10.3390/en6094607
10.1128/EC.00318-12
10.1111/j.1529-8817.1987.tb04436.x
10.1017/S0025315400019238
10.1007/s10811-006-9122-y
10.1016/0032-9592(94)80064-2
10.1016/j.jtbi.2010.04.018
10.1016/j.biortech.2016.07.055
10.1016/j.biortech.2010.06.029
10.1016/j.biortech.2010.06.138
10.1016/j.ymben.2012.01.009
10.1007/s11745-011-3624-3
10.1128/AEM.01423-14
10.1016/j.bej.2011.07.004
10.3389/fpls.2015.00474
10.1016/j.biortech.2012.05.030
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Keywords Starch and lipids optimisation
Biofuels
Kinetic modelling
Chlamydomonas reinhardtii
Microalgal dynamics
Language English
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References Morel (b0185) 1987; 23
Vlysidis, Binns, Webb, Theodoropoulos (b0220) 2011; 58–59
Rügen, Bockmayr, Legrand, Cogne (b0200) 2012; 14
Alonso, Molina, Theodoropoulos (b0010) 2014; 80
Escobar, Lora, Venturini, Yáñez, Castillo, Almazan (b0105) 2009; 13
Harris (b0130) 1989
Johnson, Alric (b0135) 2013; 12
Bekirogullari, Fragkopoulos, Pittman, Theodoropoulos (b0035) 2017; 23
Mairet, Bernard, Lacour, Sciandra (b0155) 2011
Packer, Li, Andersen, Hu, Kuang, Sommerfeld (b0190) 2011; 102
Bernard (b0040) 2011; 21
Shuler, Kargi (b0210) 1992
Kumar, Guria, Chitres, Chakraborty, Pathak (b0145) 2016; 218
Fouchard, Pruvost, Degrenne, Titica, Legrand (b0115) 2009; 102
Lee, Jalalizadeh, Zhang (b0150) 2015; 12
Chapman, Paget, Johnson, Schwartz (b0070) 2015; 6
Choix, De-Bashan, Bashan (b0080) 2012; 51
Scaife, Merkx-Jacques, Woodhall, Armenta (b0205) 2015; 44
Goodenough, Blaby, Casero, Gallaher, Goodson, Johnson, Lee, Merchant, Pellegrini, Roth, Rusch, Singh, Umen, Weiss, Wulan (b0120) 2014; 13
Zhang, Burns, Turner (b0240) 2008; 31
McNichol, MacDougall, Melanson, McGinn (b0175) 2012; 47
Behrens, Bingham, Hoeksema, Cohoon, Cox (b0030) 1989; 1
Bonachela, Raghib, Levin (b0045) 2011; 108
Juneja, Ceballos, Murthy (b0140) 2013; 6
Yao, Ai, Cao, Xue, Zhang (b0230) 2012; 118
Bougaran, Bernard, Sciandra (b0050) 2010; 265
Brennan, Owende (b0060) 2010; 14
Zhang, Chen, Johns (b0235) 1999; 35
Fan, Yan, Andre, Shanklin, Schwender, Xu (b0110) 2012; 53
Goodson, Roth, Wang, Goodenough (b0125) 2011; 10
Moon, Kim, Park, Yoo, Choi, Yang (b0180) 2013; 2
Droop (b0095) 1983; 26
Eriksen, Riisgård, Gunther, Lønsmann Iversen (b0100) 2007; 19
Turon, Baroukh, Trably, Latrille, Fouilland, Steyer (b0215) 2014; 175C
Mairet, Bernard, Masci, Lacour, Sciandra (b0160) 2011; 102
Andrews (b0015) 1968; 10
Cakmak, Angun, Demiray, Ozkan, Elibol, Tekinay (b0065) 2012; 109
Chen, Johns (b0075) 1994; 29
Dragone, Fernandes, Abreu, Vicente, Teixeira (b0085) 2011; 88
Droop (b0090) 1968; 48
Brányiková, Maršálková, Doucha, Brányik, Bišová, Zachleder, Vítová (b0055) 2010; 108
Markou, Angelidaki, Georgakakis (b0165) 2012; 96
Adesanya, Davey, Scott, Smith (b0005) 2014; 157
Ball, Deschamps (b0025) 2009
Xin, Hu, Ke, Sun (b0225) 2010; 101
Bajhaiya, Dean, Driver, Trivedi, Rattray, Allwood, Goodacre, Pittman (b0020) 2016; 12
Rodolfi, Chini Zittelli, Bassi, Padovani, Biondi, Bonini, Tredici (b0195) 2009; 102
Droop (10.1016/j.biortech.2017.05.177_b0090) 1968; 48
Yao (10.1016/j.biortech.2017.05.177_b0230) 2012; 118
Mairet (10.1016/j.biortech.2017.05.177_b0160) 2011; 102
Behrens (10.1016/j.biortech.2017.05.177_b0030) 1989; 1
Rodolfi (10.1016/j.biortech.2017.05.177_b0195) 2009; 102
Adesanya (10.1016/j.biortech.2017.05.177_b0005) 2014; 157
Dragone (10.1016/j.biortech.2017.05.177_b0085) 2011; 88
Zhang (10.1016/j.biortech.2017.05.177_b0235) 1999; 35
Packer (10.1016/j.biortech.2017.05.177_b0190) 2011; 102
Scaife (10.1016/j.biortech.2017.05.177_b0205) 2015; 44
Kumar (10.1016/j.biortech.2017.05.177_b0145) 2016; 218
Bekirogullari (10.1016/j.biortech.2017.05.177_b0035) 2017; 23
Turon (10.1016/j.biortech.2017.05.177_b0215) 2014; 175C
Alonso (10.1016/j.biortech.2017.05.177_b0010) 2014; 80
Brennan (10.1016/j.biortech.2017.05.177_b0060) 2010; 14
Fouchard (10.1016/j.biortech.2017.05.177_b0115) 2009; 102
Andrews (10.1016/j.biortech.2017.05.177_b0015) 1968; 10
Bajhaiya (10.1016/j.biortech.2017.05.177_b0020) 2016; 12
Shuler (10.1016/j.biortech.2017.05.177_b0210) 1992
Xin (10.1016/j.biortech.2017.05.177_b0225) 2010; 101
Rügen (10.1016/j.biortech.2017.05.177_b0200) 2012; 14
Bougaran (10.1016/j.biortech.2017.05.177_b0050) 2010; 265
Markou (10.1016/j.biortech.2017.05.177_b0165) 2012; 96
Chapman (10.1016/j.biortech.2017.05.177_b0070) 2015; 6
Chen (10.1016/j.biortech.2017.05.177_b0075) 1994; 29
Vlysidis (10.1016/j.biortech.2017.05.177_b0220) 2011; 58–59
Goodenough (10.1016/j.biortech.2017.05.177_b0120) 2014; 13
Eriksen (10.1016/j.biortech.2017.05.177_b0100) 2007; 19
Mairet (10.1016/j.biortech.2017.05.177_b0155) 2011
Johnson (10.1016/j.biortech.2017.05.177_b0135) 2013; 12
Choix (10.1016/j.biortech.2017.05.177_b0080) 2012; 51
Escobar (10.1016/j.biortech.2017.05.177_b0105) 2009; 13
Ball (10.1016/j.biortech.2017.05.177_b0025) 2009
Goodson (10.1016/j.biortech.2017.05.177_b0125) 2011; 10
Cakmak (10.1016/j.biortech.2017.05.177_b0065) 2012; 109
Lee (10.1016/j.biortech.2017.05.177_b0150) 2015; 12
Moon (10.1016/j.biortech.2017.05.177_b0180) 2013; 2
Zhang (10.1016/j.biortech.2017.05.177_b0240) 2008; 31
Brányiková (10.1016/j.biortech.2017.05.177_b0055) 2010; 108
Droop (10.1016/j.biortech.2017.05.177_b0095) 1983; 26
Fan (10.1016/j.biortech.2017.05.177_b0110) 2012; 53
Juneja (10.1016/j.biortech.2017.05.177_b0140) 2013; 6
Bernard (10.1016/j.biortech.2017.05.177_b0040) 2011; 21
Bonachela (10.1016/j.biortech.2017.05.177_b0045) 2011; 108
Harris (10.1016/j.biortech.2017.05.177_b0130) 1989
McNichol (10.1016/j.biortech.2017.05.177_b0175) 2012; 47
Morel (10.1016/j.biortech.2017.05.177_b0185) 1987; 23
References_xml – volume: 88
  start-page: 3331
  year: 2011
  end-page: 3335
  ident: b0085
  article-title: Nutrient limitation as a strategy for increasing starch accumulation in microalgae
  publication-title: Appl. Energy
  contributor:
    fullname: Teixeira
– volume: 21
  start-page: 1378
  year: 2011
  end-page: 1389
  ident: b0040
  article-title: Hurdles and challenges for modelling and control of microalgae for CO
  publication-title: J. Process Control
  contributor:
    fullname: Bernard
– volume: 102
  start-page: 142
  year: 2011
  end-page: 149
  ident: b0160
  article-title: Modelling neutral lipid production by the microalga
  publication-title: Bioresour. Technol.
  contributor:
    fullname: Sciandra
– volume: 51
  start-page: 294
  year: 2012
  end-page: 299
  ident: b0080
  article-title: Enhanced accumulation of starch and total carbohydrates in alginate-immobilized
  publication-title: Enzyme Microb. Technol.
  contributor:
    fullname: Bashan
– volume: 6
  start-page: 4607
  year: 2013
  end-page: 4638
  ident: b0140
  article-title: Effects of environmental factors and nutrient availability on the biochemical composition of Algae for biofuels production: a review
  publication-title: Energies
  contributor:
    fullname: Murthy
– year: 1989
  ident: b0130
  article-title: The Chlamydomonas Sourcebook : A Comprehensive Guide to Biology and Laboratory Use
  contributor:
    fullname: Harris
– volume: 19
  start-page: 161
  year: 2007
  end-page: 174
  ident: b0100
  article-title: On-line estimation of O2 production, CO2 uptake, and growth kinetics of microalgal cultures in a gas-tight photobioreactor
  publication-title: J. Appl. Phycol.
  contributor:
    fullname: Lønsmann Iversen
– volume: 102
  start-page: 232
  year: 2009
  end-page: 245
  ident: b0115
  article-title: Kinetic modeling of light limitation and sulfur deprivation effects in the induction of hydrogen production with
  publication-title: Biotechnol. Bioeng.
  contributor:
    fullname: Legrand
– volume: 12
  start-page: 497
  year: 2015
  end-page: 512
  ident: b0150
  article-title: Growth kinetic models for microalgae cultivation: a review
  publication-title: Algal Res.
  contributor:
    fullname: Zhang
– volume: 26
  start-page: 99
  year: 1983
  ident: b0095
  article-title: 25 Years of Algal growth kinetics a personal view
  publication-title: Bot. Mar.
  contributor:
    fullname: Droop
– volume: 10
  start-page: 1592
  year: 2011
  end-page: 1606
  ident: b0125
  article-title: Structural correlates of cytoplasmic and chloroplast lipid body synthesis in
  publication-title: Eukaryot Cell
  contributor:
    fullname: Goodenough
– volume: 96
  start-page: 631
  year: 2012
  end-page: 645
  ident: b0165
  article-title: Microalgal carbohydrates: an overview of the factors influencing carbohydrates production, and of main bioconversion technologies for production of biofuels
  publication-title: Appl. Microbiol. Biotechnol.
  contributor:
    fullname: Georgakakis
– volume: 35
  start-page: 385
  year: 1999
  end-page: 389
  ident: b0235
  article-title: Kinetic models for heterotrophic growth of
  publication-title: Process Biochem.
  contributor:
    fullname: Johns
– volume: 14
  start-page: 557
  year: 2010
  end-page: 577
  ident: b0060
  article-title: Biofuels from microalgae—A review of technologies for production, processing, and extractions of biofuels and co-products
  publication-title: Renew. Sustain. Energy Rev.
  contributor:
    fullname: Owende
– volume: 157
  start-page: 293
  year: 2014
  end-page: 304
  ident: b0005
  article-title: Kinetic modelling of growth and storage molecule production in microalgae under mixotrophic and autotrophic conditions
  publication-title: Bioresour. Technol.
  contributor:
    fullname: Smith
– year: 2009
  ident: b0025
  article-title: The
  contributor:
    fullname: Deschamps
– volume: 2
  start-page: 352
  year: 2013
  end-page: 357
  ident: b0180
  article-title: Mixotrophic growth with acetate or volatile fatty acids maximizes growth and lipid production in
  publication-title: Algal Res.
  contributor:
    fullname: Yang
– volume: 53
  start-page: 1380
  year: 2012
  end-page: 1390
  ident: b0110
  article-title: Oil accumulation is controlled by carbon precursor supply for fatty acid synthesis in
  publication-title: Plant Cell Physiol.
  contributor:
    fullname: Xu
– volume: 23
  start-page: 78
  year: 2017
  end-page: 87
  ident: b0035
  article-title: Production of lipid-based fuels and chemicals from microalgae: an integrated experimental and model-based optimization study
  publication-title: Algal Res.
  contributor:
    fullname: Theodoropoulos
– volume: 102
  start-page: 100
  year: 2009
  end-page: 112
  ident: b0195
  article-title: Microalgae for oil: strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor
  publication-title: Biotechnol. Bioeng.
  contributor:
    fullname: Tredici
– volume: 14
  start-page: 458
  year: 2012
  end-page: 467
  ident: b0200
  article-title: Network reduction in metabolic pathway analysis: elucidation of the key pathways involved in the photoautotrophic growth of the green alga
  publication-title: Metab. Eng.
  contributor:
    fullname: Cogne
– start-page: 10591
  year: 2011
  end-page: 10596
  ident: b0155
  article-title: Modelling microalgae growth in nitrogen limited photobiorector for estimating biomass, carbohydrate and neutral lipid
  contributor:
    fullname: Sciandra
– volume: 108
  start-page: 20633
  year: 2011
  end-page: 20638
  ident: b0045
  article-title: Dynamic model of flexible phytoplankton nutrient uptake
  publication-title: Proc. Natl. Acad. Sci.
  contributor:
    fullname: Levin
– volume: 6
  start-page: 474
  year: 2015
  ident: b0070
  article-title: Flux balance analysis reveals acetate metabolism modulates cyclic electron flow and alternative glycolytic pathways in
  publication-title: Front. Plant Sci.
  contributor:
    fullname: Schwartz
– volume: 80
  start-page: 5241
  year: 2014
  end-page: 5253
  ident: b0010
  article-title: Modeling bacterial population growth from stochastic single-cell dynamics
  publication-title: Appl. Environ. Microbiol.
  contributor:
    fullname: Theodoropoulos
– volume: 12
  start-page: 776
  year: 2013
  end-page: 793
  ident: b0135
  article-title: Central carbon metabolism and electron transport in
  publication-title: Eukaryot Cell
  contributor:
    fullname: Alric
– volume: 1
  start-page: 123
  year: 1989
  end-page: 130
  ident: b0030
  article-title: Studies on the incorporation of CO
  publication-title: J. Appl. Phycol.
  contributor:
    fullname: Cox
– volume: 175C
  start-page: 342
  year: 2014
  end-page: 349
  ident: b0215
  article-title: Use of fermentative metabolites for heterotrophic microalgae growth: Yields and kinetics
  publication-title: Bioresour. Technol.
  contributor:
    fullname: Steyer
– volume: 23
  start-page: 137
  year: 1987
  end-page: 150
  ident: b0185
  article-title: Kinetics of nutrient uptake and growth in phytoplankton
  publication-title: J. Phycol.
  contributor:
    fullname: Morel
– volume: 13
  start-page: 591
  year: 2014
  end-page: 613
  ident: b0120
  article-title: The path to triacylglyceride obesity in the sta6 strain of
  publication-title: Eukaryot Cell
  contributor:
    fullname: Wulan
– volume: 13
  start-page: 1275
  year: 2009
  end-page: 1287
  ident: b0105
  article-title: Biofuels: environment, technology and food security
  publication-title: Renew. Sustain. Energy Rev.
  contributor:
    fullname: Almazan
– volume: 44
  start-page: 620
  year: 2015
  end-page: 642
  ident: b0205
  article-title: Algal biofuels in Canada: status and potential
  publication-title: Renew. Sustain. Energy Rev.
  contributor:
    fullname: Armenta
– volume: 58–59
  start-page: 1
  year: 2011
  end-page: 11
  ident: b0220
  article-title: Glycerol utilisation for the production of chemicals: conversion to succinic acid, a combined experimental and computational study
  publication-title: Biochem. Eng. J.
  contributor:
    fullname: Theodoropoulos
– volume: 108
  start-page: 766
  year: 2010
  end-page: 776
  ident: b0055
  article-title: Microalgae—novel highly efficient starch producers
  publication-title: Biotechnol. Bioeng.
  contributor:
    fullname: Vítová
– volume: 109
  start-page: 1947
  year: 2012
  end-page: 1957
  ident: b0065
  article-title: Differential effects of nitrogen and sulfur deprivation on growth and biodiesel feedstock production of
  publication-title: Biotechnol. Bioeng.
  contributor:
    fullname: Tekinay
– volume: 29
  start-page: 245
  year: 1994
  end-page: 252
  ident: b0075
  article-title: Substrate inhibition of
  publication-title: Process Biochem.
  contributor:
    fullname: Johns
– volume: 102
  start-page: 111
  year: 2011
  end-page: 117
  ident: b0190
  article-title: Growth and neutral lipid synthesis in green microalgae: a mathematical model
  publication-title: Bioresour. Technol.
  contributor:
    fullname: Sommerfeld
– volume: 118
  start-page: 438
  year: 2012
  end-page: 444
  ident: b0230
  article-title: Enhancing starch production of a marine green microalga
  publication-title: Bioresour. Technol.
  contributor:
    fullname: Zhang
– volume: 101
  start-page: 5494
  year: 2010
  end-page: 5500
  ident: b0225
  article-title: Effects of different nitrogen and phosphorus concentrations on the growth, nutrient uptake, and lipid accumulation of a freshwater microalga Scenedesmus sp
  publication-title: Bioresour. Technol.
  contributor:
    fullname: Sun
– volume: 48
  start-page: 689
  year: 1968
  end-page: 733
  ident: b0090
  article-title: Vitamin B12 and marine ecology. IV. The Kinetics of uptake, growth and inhibition in
  publication-title: J. Mar. Biol. Assoc. U.K.
  contributor:
    fullname: Droop
– volume: 265
  start-page: 443
  year: 2010
  end-page: 454
  ident: b0050
  article-title: Modeling continuous cultures of microalgae colimited by nitrogen and phosphorus
  publication-title: J. Theor. Biol.
  contributor:
    fullname: Sciandra
– volume: 31
  start-page: 1440
  year: 2008
  end-page: 1460
  ident: b0240
  article-title: Derivation of a dynamic model of the kinetics of nitrogen uptake throughout the growth of lettuce: calibration and validation
  publication-title: J. Plant Nutr.
  contributor:
    fullname: Turner
– volume: 12
  start-page: 9
  year: 2016
  ident: b0020
  article-title: High-throughput metabolic screening of microalgae genetic variation in response to nutrient limitation
  publication-title: Metabolomics
  contributor:
    fullname: Pittman
– volume: 218
  start-page: 1021
  year: 2016
  end-page: 1036
  ident: b0145
  article-title: Modelling of microalgal growth and lipid production in
  publication-title: Bioresour. Technol.
  contributor:
    fullname: Pathak
– year: 1992
  ident: b0210
  article-title: Bioprocess Engineering: Basic Concepts
  contributor:
    fullname: Kargi
– volume: 10
  start-page: 707
  year: 1968
  end-page: 723
  ident: b0015
  article-title: A mathematical model for the continuous culture of microorganisms utilizing inhibitory substrates
  publication-title: Biotechnol. Bioeng.
  contributor:
    fullname: Andrews
– volume: 47
  start-page: 195
  year: 2012
  end-page: 207
  ident: b0175
  article-title: Suitability of soxhlet extraction to quantify microalgal fatty acids as determined by comparison with in situ transesterification
  publication-title: Lipids
  contributor:
    fullname: McGinn
– volume: 35
  start-page: 385
  year: 1999
  ident: 10.1016/j.biortech.2017.05.177_b0235
  article-title: Kinetic models for heterotrophic growth of Chlamydomonas reinhardtii in batch and fed-batch cultures
  publication-title: Process Biochem.
  doi: 10.1016/S0032-9592(99)00082-5
  contributor:
    fullname: Zhang
– volume: 1
  start-page: 123
  year: 1989
  ident: 10.1016/j.biortech.2017.05.177_b0030
  article-title: Studies on the incorporation of CO2 into starch by Chlorella vulgaris
  publication-title: J. Appl. Phycol.
  doi: 10.1007/BF00003874
  contributor:
    fullname: Behrens
– volume: 51
  start-page: 294
  year: 2012
  ident: 10.1016/j.biortech.2017.05.177_b0080
  article-title: Enhanced accumulation of starch and total carbohydrates in alginate-immobilized Chlorella spp. induced by Azospirillum brasilense: I. autotrophic conditions
  publication-title: Enzyme Microb. Technol.
  doi: 10.1016/j.enzmictec.2012.07.013
  contributor:
    fullname: Choix
– volume: 175C
  start-page: 342
  year: 2014
  ident: 10.1016/j.biortech.2017.05.177_b0215
  article-title: Use of fermentative metabolites for heterotrophic microalgae growth: Yields and kinetics
  publication-title: Bioresour. Technol.
  contributor:
    fullname: Turon
– volume: 26
  start-page: 99
  year: 1983
  ident: 10.1016/j.biortech.2017.05.177_b0095
  article-title: 25 Years of Algal growth kinetics a personal view
  publication-title: Bot. Mar.
  doi: 10.1515/botm.1983.26.3.99
  contributor:
    fullname: Droop
– volume: 108
  start-page: 20633
  year: 2011
  ident: 10.1016/j.biortech.2017.05.177_b0045
  article-title: Dynamic model of flexible phytoplankton nutrient uptake
  publication-title: Proc. Natl. Acad. Sci.
  doi: 10.1073/pnas.1118012108
  contributor:
    fullname: Bonachela
– volume: 21
  start-page: 1378
  year: 2011
  ident: 10.1016/j.biortech.2017.05.177_b0040
  article-title: Hurdles and challenges for modelling and control of microalgae for CO2 mitigation and biofuel production
  publication-title: J. Process Control
  doi: 10.1016/j.jprocont.2011.07.012
  contributor:
    fullname: Bernard
– volume: 101
  start-page: 5494
  year: 2010
  ident: 10.1016/j.biortech.2017.05.177_b0225
  article-title: Effects of different nitrogen and phosphorus concentrations on the growth, nutrient uptake, and lipid accumulation of a freshwater microalga Scenedesmus sp
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2010.02.016
  contributor:
    fullname: Xin
– volume: 157
  start-page: 293
  year: 2014
  ident: 10.1016/j.biortech.2017.05.177_b0005
  article-title: Kinetic modelling of growth and storage molecule production in microalgae under mixotrophic and autotrophic conditions
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2014.01.032
  contributor:
    fullname: Adesanya
– volume: 13
  start-page: 1275
  year: 2009
  ident: 10.1016/j.biortech.2017.05.177_b0105
  article-title: Biofuels: environment, technology and food security
  publication-title: Renew. Sustain. Energy Rev.
  doi: 10.1016/j.rser.2008.08.014
  contributor:
    fullname: Escobar
– volume: 96
  start-page: 631
  year: 2012
  ident: 10.1016/j.biortech.2017.05.177_b0165
  article-title: Microalgal carbohydrates: an overview of the factors influencing carbohydrates production, and of main bioconversion technologies for production of biofuels
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-012-4398-0
  contributor:
    fullname: Markou
– volume: 10
  start-page: 707
  year: 1968
  ident: 10.1016/j.biortech.2017.05.177_b0015
  article-title: A mathematical model for the continuous culture of microorganisms utilizing inhibitory substrates
  publication-title: Biotechnol. Bioeng.
  doi: 10.1002/bit.260100602
  contributor:
    fullname: Andrews
– volume: 53
  start-page: 1380
  year: 2012
  ident: 10.1016/j.biortech.2017.05.177_b0110
  article-title: Oil accumulation is controlled by carbon precursor supply for fatty acid synthesis in Chlamydomonas reinhardtii
  publication-title: Plant Cell Physiol.
  doi: 10.1093/pcp/pcs082
  contributor:
    fullname: Fan
– year: 1989
  ident: 10.1016/j.biortech.2017.05.177_b0130
  contributor:
    fullname: Harris
– volume: 31
  start-page: 1440
  year: 2008
  ident: 10.1016/j.biortech.2017.05.177_b0240
  article-title: Derivation of a dynamic model of the kinetics of nitrogen uptake throughout the growth of lettuce: calibration and validation
  publication-title: J. Plant Nutr.
  doi: 10.1080/01904160802208345
  contributor:
    fullname: Zhang
– start-page: 10591
  year: 2011
  ident: 10.1016/j.biortech.2017.05.177_b0155
  article-title: Modelling microalgae growth in nitrogen limited photobiorector for estimating biomass, carbohydrate and neutral lipid
  contributor:
    fullname: Mairet
– volume: 102
  start-page: 100
  year: 2009
  ident: 10.1016/j.biortech.2017.05.177_b0195
  article-title: Microalgae for oil: strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor
  publication-title: Biotechnol. Bioeng.
  doi: 10.1002/bit.22033
  contributor:
    fullname: Rodolfi
– volume: 102
  start-page: 232
  year: 2009
  ident: 10.1016/j.biortech.2017.05.177_b0115
  article-title: Kinetic modeling of light limitation and sulfur deprivation effects in the induction of hydrogen production with Chlamydomonas reinhardtii: part I. Model development and parameter identification
  publication-title: Biotechnol. Bioeng.
  doi: 10.1002/bit.22034
  contributor:
    fullname: Fouchard
– volume: 23
  start-page: 78
  year: 2017
  ident: 10.1016/j.biortech.2017.05.177_b0035
  article-title: Production of lipid-based fuels and chemicals from microalgae: an integrated experimental and model-based optimization study
  publication-title: Algal Res.
  doi: 10.1016/j.algal.2016.12.015
  contributor:
    fullname: Bekirogullari
– volume: 109
  start-page: 1947
  year: 2012
  ident: 10.1016/j.biortech.2017.05.177_b0065
  article-title: Differential effects of nitrogen and sulfur deprivation on growth and biodiesel feedstock production of Chlamydomonas reinhardtii
  publication-title: Biotechnol. Bioeng.
  doi: 10.1002/bit.24474
  contributor:
    fullname: Cakmak
– volume: 2
  start-page: 352
  year: 2013
  ident: 10.1016/j.biortech.2017.05.177_b0180
  article-title: Mixotrophic growth with acetate or volatile fatty acids maximizes growth and lipid production in Chlamydomonas reinhardtii
  publication-title: Algal Res.
  doi: 10.1016/j.algal.2013.09.003
  contributor:
    fullname: Moon
– volume: 10
  start-page: 1592
  year: 2011
  ident: 10.1016/j.biortech.2017.05.177_b0125
  article-title: Structural correlates of cytoplasmic and chloroplast lipid body synthesis in Chlamydomonas reinhardtii and stimulation of lipid body production with acetate boost
  publication-title: Eukaryot Cell
  doi: 10.1128/EC.05242-11
  contributor:
    fullname: Goodson
– volume: 13
  start-page: 591
  year: 2014
  ident: 10.1016/j.biortech.2017.05.177_b0120
  article-title: The path to triacylglyceride obesity in the sta6 strain of Chlamydomonas reinhardtii
  publication-title: Eukaryot Cell
  doi: 10.1128/EC.00013-14
  contributor:
    fullname: Goodenough
– volume: 12
  start-page: 497
  year: 2015
  ident: 10.1016/j.biortech.2017.05.177_b0150
  article-title: Growth kinetic models for microalgae cultivation: a review
  publication-title: Algal Res.
  doi: 10.1016/j.algal.2015.10.004
  contributor:
    fullname: Lee
– volume: 14
  start-page: 557
  year: 2010
  ident: 10.1016/j.biortech.2017.05.177_b0060
  article-title: Biofuels from microalgae—A review of technologies for production, processing, and extractions of biofuels and co-products
  publication-title: Renew. Sustain. Energy Rev.
  doi: 10.1016/j.rser.2009.10.009
  contributor:
    fullname: Brennan
– volume: 12
  start-page: 9
  year: 2016
  ident: 10.1016/j.biortech.2017.05.177_b0020
  article-title: High-throughput metabolic screening of microalgae genetic variation in response to nutrient limitation
  publication-title: Metabolomics
  doi: 10.1007/s11306-015-0878-4
  contributor:
    fullname: Bajhaiya
– volume: 88
  start-page: 3331
  year: 2011
  ident: 10.1016/j.biortech.2017.05.177_b0085
  article-title: Nutrient limitation as a strategy for increasing starch accumulation in microalgae
  publication-title: Appl. Energy
  doi: 10.1016/j.apenergy.2011.03.012
  contributor:
    fullname: Dragone
– volume: 44
  start-page: 620
  year: 2015
  ident: 10.1016/j.biortech.2017.05.177_b0205
  article-title: Algal biofuels in Canada: status and potential
  publication-title: Renew. Sustain. Energy Rev.
  doi: 10.1016/j.rser.2014.12.024
  contributor:
    fullname: Scaife
– volume: 108
  start-page: 766
  year: 2010
  ident: 10.1016/j.biortech.2017.05.177_b0055
  article-title: Microalgae—novel highly efficient starch producers
  publication-title: Biotechnol. Bioeng.
  doi: 10.1002/bit.23016
  contributor:
    fullname: Brányiková
– volume: 6
  start-page: 4607
  year: 2013
  ident: 10.1016/j.biortech.2017.05.177_b0140
  article-title: Effects of environmental factors and nutrient availability on the biochemical composition of Algae for biofuels production: a review
  publication-title: Energies
  doi: 10.3390/en6094607
  contributor:
    fullname: Juneja
– volume: 12
  start-page: 776
  year: 2013
  ident: 10.1016/j.biortech.2017.05.177_b0135
  article-title: Central carbon metabolism and electron transport in Chlamydomonas reinhardtii: metabolic constraints for carbon partitioning between oil and starch
  publication-title: Eukaryot Cell
  doi: 10.1128/EC.00318-12
  contributor:
    fullname: Johnson
– volume: 23
  start-page: 137
  year: 1987
  ident: 10.1016/j.biortech.2017.05.177_b0185
  article-title: Kinetics of nutrient uptake and growth in phytoplankton
  publication-title: J. Phycol.
  doi: 10.1111/j.1529-8817.1987.tb04436.x
  contributor:
    fullname: Morel
– volume: 48
  start-page: 689
  year: 1968
  ident: 10.1016/j.biortech.2017.05.177_b0090
  article-title: Vitamin B12 and marine ecology. IV. The Kinetics of uptake, growth and inhibition in Monochrysis Lutheri
  publication-title: J. Mar. Biol. Assoc. U.K.
  doi: 10.1017/S0025315400019238
  contributor:
    fullname: Droop
– volume: 19
  start-page: 161
  year: 2007
  ident: 10.1016/j.biortech.2017.05.177_b0100
  article-title: On-line estimation of O2 production, CO2 uptake, and growth kinetics of microalgal cultures in a gas-tight photobioreactor
  publication-title: J. Appl. Phycol.
  doi: 10.1007/s10811-006-9122-y
  contributor:
    fullname: Eriksen
– volume: 29
  start-page: 245
  year: 1994
  ident: 10.1016/j.biortech.2017.05.177_b0075
  article-title: Substrate inhibition of Chlamydomonas reinhardtii by acetate in heterotrophic culture
  publication-title: Process Biochem.
  doi: 10.1016/0032-9592(94)80064-2
  contributor:
    fullname: Chen
– volume: 265
  start-page: 443
  year: 2010
  ident: 10.1016/j.biortech.2017.05.177_b0050
  article-title: Modeling continuous cultures of microalgae colimited by nitrogen and phosphorus
  publication-title: J. Theor. Biol.
  doi: 10.1016/j.jtbi.2010.04.018
  contributor:
    fullname: Bougaran
– volume: 218
  start-page: 1021
  year: 2016
  ident: 10.1016/j.biortech.2017.05.177_b0145
  article-title: Modelling of microalgal growth and lipid production in Dunaliella tertiolecta using nitrogen-phosphorus-potassium fertilizer medium in sintered disk chromatographic glass bubble column
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2016.07.055
  contributor:
    fullname: Kumar
– year: 1992
  ident: 10.1016/j.biortech.2017.05.177_b0210
  contributor:
    fullname: Shuler
– volume: 102
  start-page: 111
  year: 2011
  ident: 10.1016/j.biortech.2017.05.177_b0190
  article-title: Growth and neutral lipid synthesis in green microalgae: a mathematical model
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2010.06.029
  contributor:
    fullname: Packer
– volume: 102
  start-page: 142
  year: 2011
  ident: 10.1016/j.biortech.2017.05.177_b0160
  article-title: Modelling neutral lipid production by the microalga Isochrysis aff. galbana under nitrogen limitation
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2010.06.138
  contributor:
    fullname: Mairet
– volume: 14
  start-page: 458
  year: 2012
  ident: 10.1016/j.biortech.2017.05.177_b0200
  article-title: Network reduction in metabolic pathway analysis: elucidation of the key pathways involved in the photoautotrophic growth of the green alga Chlamydomonas reinhardtii
  publication-title: Metab. Eng.
  doi: 10.1016/j.ymben.2012.01.009
  contributor:
    fullname: Rügen
– volume: 47
  start-page: 195
  year: 2012
  ident: 10.1016/j.biortech.2017.05.177_b0175
  article-title: Suitability of soxhlet extraction to quantify microalgal fatty acids as determined by comparison with in situ transesterification
  publication-title: Lipids
  doi: 10.1007/s11745-011-3624-3
  contributor:
    fullname: McNichol
– volume: 80
  start-page: 5241
  year: 2014
  ident: 10.1016/j.biortech.2017.05.177_b0010
  article-title: Modeling bacterial population growth from stochastic single-cell dynamics
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.01423-14
  contributor:
    fullname: Alonso
– volume: 58–59
  start-page: 1
  year: 2011
  ident: 10.1016/j.biortech.2017.05.177_b0220
  article-title: Glycerol utilisation for the production of chemicals: conversion to succinic acid, a combined experimental and computational study
  publication-title: Biochem. Eng. J.
  doi: 10.1016/j.bej.2011.07.004
  contributor:
    fullname: Vlysidis
– volume: 6
  start-page: 474
  year: 2015
  ident: 10.1016/j.biortech.2017.05.177_b0070
  article-title: Flux balance analysis reveals acetate metabolism modulates cyclic electron flow and alternative glycolytic pathways in Chlamydomonas reinhardtii
  publication-title: Front. Plant Sci.
  doi: 10.3389/fpls.2015.00474
  contributor:
    fullname: Chapman
– volume: 118
  start-page: 438
  year: 2012
  ident: 10.1016/j.biortech.2017.05.177_b0230
  article-title: Enhancing starch production of a marine green microalga Tetraselmis subcordiformis through nutrient limitation
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2012.05.030
  contributor:
    fullname: Yao
– year: 2009
  ident: 10.1016/j.biortech.2017.05.177_b0025
  contributor:
    fullname: Ball
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Snippet •We developed a new kinetic model to predict microalgal starch and lipid formation.•Model dynamics were experimentally validated for a range of conditions.•The...
Microalgal starch and lipids, carbon-based storage molecules, are useful as potential biofuel feedstocks. In this work, cultivation strategies maximising...
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SubjectTerms Biofuels
Biomass
Chlamydomonas reinhardtii
Kinetic modelling
Lipids
Microalgae
Microalgal dynamics
Starch
Starch and lipids optimisation
Title Kinetic modelling of starch and lipid formation during mixotrophic, nutrient-limited microalgal growth
URI https://dx.doi.org/10.1016/j.biortech.2017.05.177
https://www.ncbi.nlm.nih.gov/pubmed/28628990
https://search.proquest.com/docview/1911699981
Volume 241
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