The identification of [2-14C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans - Malfatti, Michael A.; Kulp, Kristen S.; Knize, Mark G.; Davis, Cindy; Massengill, Joyce P.; Williams, Suzanne; Nowell, Susan; MacLeod, Stewart; Dingley, Karen H.; Turteltaub, Kenneth W.; Lang, Nicholas P.; Felton, James S. (Carcinogenesis (New York), 1999)
Keywords: 2-amino-1-methyl-6-(4′-hydroxy)phenylimidazo; 2-amino-1-methyl-6-phenylimidazo; 2-hydroxyamino-1-methyl-6-phenylimidazo; 4′-(2-amino-1-methylimidazo; 4′-hydroxy-PhIP; 4′-PhIP-sulfate; 5-b]pyrid-6-yl) phenyl sulfate; 5-b]pyridine; Administration, Oral; Aged; Aged, 80 and over; Animals; Biological and medical sciences; Biotransformation; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens - administration & dosage; Carcinogens - analysis; Carcinogens - pharmacokinetics; Chemical agents; Chromatography, High Pressure Liquid; CID; collision induced dissociation; Colonic Neoplasms - metabolism; CYP1A2; Cytochrome P-450 CYP1A2 - genetics; Cytochrome P-450 CYP1A2 - metabolism; cytochrome P4501A2; Dogs; Glucuronates - urine; heterocyclic amine; Hot Temperature; Humans; Imidazoles - administration & dosage; Imidazoles - blood; Imidazoles - pharmacokinetics; Imidazoles - urine; Male; Meat; Medical sciences; Mice; Microsomes, Liver - enzymology; Molecular Structure; N-acetyltransferase; N-hydroxy-PhIP; NAT2; Phenotype; PhIP; retention time; Species Specificity; sulfotransferase; Tumors; UDP–glucuronosyltransferase; UDP–GT; Human; Biological fluid; Metabolite; Oral administration; Metabolic pathway; Malignant tumor; Blood; Blood plasma; Colonic disease; Carcinogen; Digestive diseases; Intestinal disease; Colon; Pharmacokinetics; Radiopharmaceuticals