Use of gene regulatory network analysis to repurpose drugs to treat bipolar disorder

• Published in: Journal of affective disorders Vol. 350; pp. 230 - 239
• Main Authors: Truong, Trang T.T., Liu, Zoe S.J., Panizzutti, Bruna, Dean, Olivia M., Berk, Michael, Kim, Jee Hyun, Walder, Ken
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2024
• Subjects: Bipolar disorder; Bipolar Disorder - drug therapy; Bipolar Disorder - genetics; Bipolar Disorder - metabolism; Brain - metabolism; Drug discovery; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Mental disorders; Network analysis; Neuroscience; Psychiatric/Mental Health; Psychiatry; Bipolar disorder; Neuroscience; Drug discovery; Mental disorders; Psychiatry; Network analysis

Bipolar disorder (BD) presents significant challenges in drug discovery, necessitating alternative approaches. Drug repurposing, leveraging computational techniques and expanding biomedical data, holds promise for identifying novel treatment strategies. This study utilized gene regulatory networks (...